Preparation and xenotransplantation of porcine islets

Details Preparation and xenotransplantation of porcine islets Preparation and xenotransplantation of porcine islets

2006-10-17

2006-10-17

Li, Q. Janice (Department: 1633)

Drug, bio-affecting and body treating compositions

Whole live micro-organism, cell, or virus containing

C435S325000

Reexamination Certificate

active

07122177

ABSTRACT:
The invention relates to developments in the treatment of diabetes in mammals. Particularly it relates to a method of preparing a xenotransplantable porcine islet preparation capable upon xenotransplantation of producing porcine insulin in an appropriate recipient mammal, the method including or comprising the steps of:(I) harvesting the pancreas of piglets at or near full term gestation, and(ii) extracting pancreatic β islet cells from the harvested pancreas wherein the islets (at least at some stage in the performance of the method) are exposed to nicotinamide.Further, the invention relates to a method of encapsulation of a xenotransplantable porcine islet preparation, and transplantation of such a preparation, or a capsule containing such a preparation, into an appropriate recipient mammal.

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