Preparation and utilization of a novel sterile albumin

Details Preparation and utilization of a novel sterile albumin Preparation and utilization of a novel sterile albumin

1997-12-22

1999-07-06

Tsang, Cecilia

Chemistry: natural resins or derivatives; peptides or proteins;

Proteins, i.e., more than 100 amino acid residues

Albumin

530363, 530364, 530416, 530417, 530419, 530421, 530427, 530812, 530813, 530815, 424 7825, 424405, 424406, 514 2, 514 5, 514 21, 514 59, 514 60, C07K 100, A01N 4304, A61K 3318

Patent

active

059199075

ABSTRACT:
A method of preparing a novel, sterile, receptor rich-albumin molecule which utilizes the disinfecting properties of iodine by reacting an iodine donating material or solution with a pure preparation of albumin, and preferably subsequently removing the iodine. The resulting iodine has improved binding properties because the production method strips bacterial endotoxin and other previously bound substances from the albumin. The improved binding site capacity of the albumin product is advantageously used as an adjunct in removing toxins by means of exchange transfusions. Because iodine disinfects the albumin typical pasteurization and related additives are unnecessary.

REFERENCES:
patent: 5071648 (1991-12-01), Rosenblatt
patent: 5250663 (1993-10-01), Tenold
patent: 5346992 (1994-09-01), Grandgeorge et al.
patent: 5370869 (1994-12-01), Shanbrom
Highsmith et al., Blood, vol. 86, No. 2, pp. 791-796, 1995.

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