Preparation and uses of stable, bound stationary phases

Details Preparation and uses of stable, bound stationary phases Preparation and uses of stable, bound stationary phases

1975-02-27

1976-10-19

Adee, John

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

55386, 210198C, 210502, 26032631, 260505A, 260499, 260430, 252426, 210 31C, B01D 1508

Patent

active

039870588

ABSTRACT:
Sulfobenzylsilicas in which the organic moiety is bound to silica surfaces through a carbon-silicon bond are prepared by treating silica with thionyl chloride to chlorinate reactive silanol groups, reacting the product with benzyllithium and sulfonating the resulting benzylsilica. The sulfobenzylsilicas and their salts of noble metals are useful as bound stationary phases in various chromatographic procedures for the separation of a wide variety of natural product mixtures composed of closely related chemical compounds. For example, separation of methyl cis 9-octadecenoate and methyl trans 9-octadecenoate was readily achieved by gas-liquid chromatography on a modified silver sulfobenzylsilica column.

REFERENCES:
patent: 3598767 (1971-08-01), Kovacs et al.
patent: 3655615 (1972-04-01), Bush et al.
patent: 3722181 (1973-03-01), Kirkland et al.
patent: 3878092 (1975-04-01), Fuller
Introduction to Modern Liquid Chromatography by Snyder and Kirkland, John Wiley and Sons, New York, N.Y. 1974, pp. 294-299 relied on.

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