Preparation and use of viral vectors for mixed envelope protein

Details Preparation and use of viral vectors for mixed envelope protein Preparation and use of viral vectors for mixed envelope protein

1997-01-23

1998-12-08

Achutamurthy, Ponnathapura

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Combination of antigens from multiple viral species

4241911, 4242081, 514 44, 536 2372, A61K 39295, A61K 3912, A61K 3921, A01N 4304

Patent

active

058465464

ABSTRACT:
Polyenv immunogenic composition are provided that comprise mixtures of at least 4 different recombinant viruses that each express a different HIV env variant or a portion thereof containing both constant and variable regions, as well as methods of making and using such polyenv immunogenic composition and viruses. The immunogenic composition of the invention are optimally combined with a recombinant HIV env booster, or a recombinant HIV env gene DNA priming or boosting vaccine.

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