Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1997-10-06
1999-07-27
Davis, Zinna Northington
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
514211, 5142382, 514255, 514327, 514338, 514342, 514343, 514424, 514454, 514602, 514604, 540526, 544158, 544384, 546195, 546216, 5462784, 5462801, 5462804, 5462831, 546293, 548565, 549236, 564 84, 564 90, C07D21302, C07C31108, A61K 3118, A61K 3144
Patent
active
059290978
ABSTRACT:
The present invention relates to the discovery of novel, low molecular weight, non-peptide inhibitors of matrix metalloproteinases (e.g. gelatinases, stromelysins and collagenases) and TNF-.alpha. converting enzyme (TACE, tumor necrosis factor-.alpha. converting enzyme) which are useful for the treatment of diseases in which these enzymes are implicated such as arthritis, tumor growth and metastasis, angiogenesis, tissue ulceration, abnormal wound healing, periodontal disease, bone disease, proteinuria, aneurysmal aortic disease, degenerative cartilage loss following traumatic joint injury, demyelinating diseases of the nervous system, graft rejection, cachexia, anorexia, inflammation, fever, insulin resistance, septic shock, congestive heart failure, inflammatory disease of the central nervous system, inflammatory bowel disease, HIV infection, age related macular degeneration, diabetic retinopathy, proliferative vitreoretinopathy, retinopathy of prematurity, ocular inflammation, keratoconus, Sjogren's syndrome, myopia, ocular tumors, ocular angiogenesis
eovascularization.
The TACE and MMP inhibiting ortho-sulfonamido aryl hydroxamic acids of the present invention are represented by the formula ##STR1## where the hydroxamic acid moiety and the sulfonamido moiety are bonded to adjacent carbons on group A.
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patent: 5552419 (1996-09-01), MacPherson et al.
Kato et al, Chemical Abstracts, vol. 126, No. 1, Abstract No. 7829f, p. 872, Jan. 6, 1997.
Priewe et al, Chemical Abstracts, vol. 52, No. 9, Abstract No. 10184d, May 10, 1958.
Du Mila T.
Gu Yansong
Levin Jeremy Ian
Nelson Frances Christy
Venkatesan Aranapakam Mudumbai
American Cyanamid Company
Barrett Rebecca R.
Davis Zinna Northington
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