Preparation and use of novel injectable RES avoiding inorganic p

Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Particulate form

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424 91, 424 93, A61K 916, A61K 950

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active

055476821

ABSTRACT:
Novel N-RES agents for use in vitro and in vivo medical and biological applications, such as, for example MRI and/or intravenous administration of pharmaceutical agents are described. The novel N-RES agents are prepared by coating inorganic core particles with a poly(acrylic acid)--poly(alkylene ether) graft copolymer. The resulting polymer-coated inorganic particle cores are useful as imaging agents, therapeutic agents or carriers having increased circulation time due to decrease uptake or recognition by the RES.

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