Preparation and use of new solvates of beclomethasone 17,21-dipr

Details Preparation and use of new solvates of beclomethasone 17,21-dipr Preparation and use of new solvates of beclomethasone 17,21-dipr

1985-07-24

1990-04-03

Lipovsky, Joseph A.

Drug, bio-affecting and body treating compositions

Effervescent or pressurized fluid containing

Organic pressurized fluid

552574, 514 80, A61K 3156, C07J 100, A61L 904

Patent

active

049138928

ABSTRACT:
Preparation of novel solvates of beclomethasone 17,21-dipropionate, by dissolution of beclomethasone 17,21-dipropionate in an ethereal or halogenated hydrocarbon solvent and precipitation by the addition of di-isopropyl ether. These new solvates are bulk stable, in both the micronized and non-micronized forms. The micronized form is especially suitable for the preparation of stable aerosol.

REFERENCES:
patent: 4044126 (1977-08-01), Cook et al.
Chemical Abstracts. vol. 80 (1974), Par. 19542(b) relied on.

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