Chemistry: molecular biology and microbiology – Carrier-bound or immobilized enzyme or microbial cell;... – Enzyme or microbial cell is immobilized on or in an organic...
Reexamination Certificate
2000-01-10
2001-11-13
Naff, David M. (Department: 1651)
Chemistry: molecular biology and microbiology
Carrier-bound or immobilized enzyme or microbial cell;...
Enzyme or microbial cell is immobilized on or in an organic...
C209S008000, C210S222000, C252S06251C, C435S176000, C435S180000, C435S280000, C436S525000, C436S531000, C526S095000
Reexamination Certificate
active
06316235
ABSTRACT:
FIELD OF THE INVENTION
The present invention is broadly directed to magnetically susceptible polymer particles having specifically-tailored adsorptivities and to related processes. The invention also encompasses the related processes:
(i) for making the particles;
(ii) for separating target compounds from other compounds using the particles; and
(iii) for delivering selected compounds to targeted areas of concentration using the particles.
Of particular interest are particles and processes that involve biologically active substances, e.g., pharmaceuticals.
BACKGROUND OF THE INVENTION
In describing the invention along with the background thereof, certain documents are either explicitly discussed or are relevant sources of background information. These documents are indicated by number (e.g. “document 1”) throughout the remainder of the specification and are identified immediately prior to the claims. The present application incorporates by reference the entire contents of each of these documents.
Biologically active substances are often produced in relatively small quantities in processes wherein the desired final product is frequently in the presence of other, perhaps numerous, undesired compounds, mixtures, etc. The cost in terms of time, money, or equipment of isolating and/or purifying the desired product from the undesired product can be very significant. The cost for these post-production processes is ultimately borne by the purchaser of the desired product. As such, there is a continuing need in the art for materials and/or processes that improve the isolation and/or purification of compounds produced by biotechnological processes.
Existing isolation and/or purification techniques may include: (i) multistep bulk processes such as fractional crystallization; distillation, etc; or (ii) reactant conditions designed to produce only the desired product. The disadvantages of the techniques of (i) include relativity complicated processing and possible purification problems. The disadvantages of the techniques of (ii) include the high costs of obtaining such reactant conditions. For example, by using only particular enantiomers of particular reactants, it is possible to obtain a relatively high degree of purity in a desired chiral product (i.e., a unique enantiomer of the desired product). However, this process necessitates controlling the exact stereochemistry of all of the individual reactions which culminate in the formation of the desired enantiomeric product. This stereochemically control requires the use of particular enantiomeric forms of all the reactant compounds and is accordingly relatively expensive as compared to running reactions without using enantiomerically-pure compounds.
As will be apparent to those workers of ordinary skill in the art, the present invention directed to magnetically susceptible polymer particles having specifically-tailored adsorptivities and to processes employing such particles represents a patentable advance in the art and offers advantages over existing techniques.
SUMMARY OF THE INVENTION
The present invention is directed to magnetically susceptible polymer particles wherein the polymeric core of the particles has both specifically-tailored adsorptivities and magnetically susceptible components. Alternative embodiments of the present invention include the following related processes:
(i) for making the particles;
(ii) for separating target compounds from other compounds using the particles; and
(iii) for delivering selected compounds to targeted areas of concentration using the particles.
The selective adsorptivities of the particles arise from a combination of selective adsorbents and/or from molecular memory recognition sites (typically from molecular imprinting polymerization reactions). The particles are magnetically susceptible because of the presence of magnetically susceptible components such as metal oxides in intimate proximity to the polymeric core of the particles.
REFERENCES:
patent: 3970518 (1976-07-01), Giaever
patent: 3985649 (1976-10-01), Eddelman
patent: 4106488 (1978-08-01), Gordon
patent: 4115534 (1978-09-01), Ithakissios
patent: 4335094 (1982-06-01), Mosbach
patent: 5418151 (1995-05-01), Goodhue et al.
patent: 8604087 (1986-07-01), None
Kempe, Marie, Chiral Recognition, Doctoral Dissertation, Department of Pure and Applied Biochemistry, University of Lund, Sweden, pp. 1-77 (1994).*
Andersson, et. al., Bioseparation and Catlaysis in Molecularly Imprinted Polymers. Molecular Interactions in Bioseparations, pp. 383-394 (1993).*
Wulff, et. al., J. Org. Chem., vol. 56, No. 1, pp. 395-400 (1991).*
Wulff, Gunter, The Role of Binding-Site Interactions in the Molecular Imprinting of Polymers, Eisevier Science Publishers, pp. 85-87 (1993).
Ansell Richard J.
Kriz Dario
Mosbach Klaus
IGEN, Inc.
Morgan & Finnegan , LLP
Naff David M.
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