Preparation and use of bouvardin and deoxybouvardin

Details Preparation and use of bouvardin and deoxybouvardin Preparation and use of bouvardin and deoxybouvardin

1978-11-20

1980-10-07

Phillips, Delbert R.

Drug, bio-affecting and body treating compositions

Immunoglobulin, antiserum, antibody, or antibody fragment,...

Reduced antigenicity, reduced ability to bind complement, or...

2601125R, A61K 3700, C07C10352, C07G 700

Patent

active

042268567

ABSTRACT:
Bouvardin (C.sub.40 H.sub.48 N.sub.6 O.sub.10) and deoxybouvardin (C.sub.40 H.sub.48 -N.sub.6 O.sub.9), bicyclic hexapeptides isolated from Bouvardia ternifolia are provided in the form of pure materials, individually, and as a mixture with each other. The pure materials exhibit significant anti-neoplastic disease activity in vivo and in vitro.

REFERENCES:
Jolad, S., et al., J. American Chem. Soc., 99, pp. 8040-8044 (1977).

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