Organic compounds -- part of the class 532-570 series – Organic compounds – Hydroxamic acids – chalcogen analogs or salts thereof
Patent
1997-10-06
1999-11-02
Geist, Gary
Organic compounds -- part of the class 532-570 series
Organic compounds
Hydroxamic acids, chalcogen analogs or salts thereof
562621, C07C31129
Patent
active
059774088
ABSTRACT:
The present invention relates to the discovery of novel, low molecular weight, non-peptide inhibitors of matrix metalloproteinases (e.g. gelatinases, stromelysins and collagenases) and TNF-.alpha. converting enzyme (TACE, tumor necrosis factor-.alpha. converting enzyme) which are useful for the treatment of diseases in which these enzymes are implicated such as arthritis, tumor growth and metastasis, angiogenesis, tissue ulceration, abnormal wound healing, periodontal disease, bone disease, proteinuria, aneurysmal aortic disease, degenerative cartilage loss following traumatic joint injury, demyelinating diseases of the nervous system, graft rejection, cachexia, anorexia, inflammation, fever, insulin resistance, septic shock, congestive heart failure, inflammatory disease of the central nervous system, inflammatory bowel disease, HIV infection, age related macular degeneration, diabetic retinopathy, proliferative vitreoretinopathy, retinopathy of prematurity, ocular inflammation, keratoconus, Sjogren's syndrome, myopia, ocular tumors, ocular angiogenesis
eovascularization.
The TACE and MMP inhibiting ortho-sulfonamido aryl hydroxamic acids of the present invention are represented by the formula ##STR1## where the hydroxamic acid moiety and the sulfonamido moiety are bonded to adjacent carbons on group A where:
REFERENCES:
patent: 5455258 (1995-10-01), MacPherson et al.
patent: 5506242 (1996-04-01), MacPherson et al.
patent: 5552419 (1996-09-01), MacPherson et al.
J. Med. Chem., 40, 2525, MacPherson et al. (1997).
Gu Yansong
Levin Jeremy Ian
Zask Arie
American Cyanamid Company
Barrett Rebecca R.
Davis Brian J.
Geist Gary
LandOfFree
Preparation and use of .beta.-sulfonamido hydroxamic acids as ma does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Preparation and use of .beta.-sulfonamido hydroxamic acids as ma, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Preparation and use of .beta.-sulfonamido hydroxamic acids as ma will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-2137571