Preparation and purification of citrovorum factor

Details Preparation and purification of citrovorum factor Preparation and purification of citrovorum factor

1977-08-22

1979-04-10

Coughlan, Jr., Paul M.

Organic compounds -- part of the class 532-570 series

Organic compounds

Four or more ring nitrogens in the bicyclo ring system

544251, C07D47504

Patent

active

041489993

ABSTRACT:
Improved methods for the preparation and purification of citrovorum factor are disclosed. The method includes improved procedures for hydrogenation of 10-formylfolic acid as well as for the reduction of folic acid. Also disclosed are improved procedures for opening of the imidazoline ring, and a non-chromatographic method for the purification of crude samples of citrovorum factor.

REFERENCES:
patent: 2594271 (1952-04-01), Fahrenbach
patent: 2737515 (1956-03-01), Brockman et al.
patent: 2739966 (1956-03-01), Brockman et al.
patent: 2741608 (1956-04-01), Shive
patent: 2927113 (1960-03-01), D'Amato
patent: 3983118 (1976-09-01), Knott et al.

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