Prenatal down syndrome screening with assays specific for UGP

Details Prenatal down syndrome screening with assays specific for UGP Prenatal down syndrome screening with assays specific for UGP

1996-04-30

1998-02-10

Woodward, Michael P.

Chemistry: analytical and immunological testing

Immunochemical pregnancy determination

436814, 435 71, 435 772, 435 79, 435 792, 435 793, 435 794, 435 795, 530398, G01N 3376, G01N 33577, C07K 1459

Patent

active

057168539

ABSTRACT:
Herein disclosed are methods for prenatally assessing risks of a pregnancy being affected by Down syndrome by testing maternal urine samples for levels of urinary gonadotropin peptide (UGP) elevated above normal. The methods employ immunoassays that are highly specific for UGP and have molar cross-reactivities of less than about 10% with intact hCG, with .beta.-subunit hCG, and with .alpha.-subunit hCG. The immunoassay methods of this invention are useful to test first trimester maternal urine samples. Among other benefits, first trimester prenatal screening provides the opportunity to terminate the pregnancy at an early gestational age, in the case of an unfavorable outcome.

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