Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...
Reexamination Certificate
2007-07-03
2007-07-03
Pak, Michael (Department: 1646)
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving antigen-antibody binding, specific binding protein...
C435S007800, C435S024000
Reexamination Certificate
active
09276935
ABSTRACT:
The present invention relates to a novel human orphan nuclear receptor that binds to a cytochrome P-450 monooxygenase (CYP) promoter and that is activated by compounds that induce CYP gene expression. The invention further relates to nucleic acid sequences encoding such a receptor, to methods of making the receptor and to methods of using the receptor and nucleic acid sequences encoding same. The invention also relates to non-human animals transformed to express the human receptor and to methods of using such animals to screen compounds for drug interactions and toxicities.
REFERENCES:
patent: 2003/0033279 (2003-02-01), Berkenstam et al.
patent: 2003/0064430 (2003-04-01), Evans et al.
patent: 11-127872 (1999-05-01), None
patent: WO 96/22390 (1996-07-01), None
patent: WO 99/19354 (1999-04-01), None
patent: WO 99/31129 (1999-06-01), None
patent: WO 99/35246 (1999-07-01), None
patent: WO 99/48915 (1999-09-01), None
patent: WO 00/37077 (2000-06-01), None
patent: WO 01/97856 (2001-12-01), None
Bowie et al. (1990) Science 247: 1307-1310.
Maurel, P., “Cytochromes P450: Metabolic and Toxicological Aspects”, (ed. loannides, C.), pp. 241-270 (CRC Press, Inc., Boca Raton, Fl (1996).
Guzelian, P.S. “Microsomes and Drug Oxidations” (eds. Miners et al), pp. 148-155 (Taylor and Francis, London (1988).
Hashimoto et al, “Gene structure of CYP3A5, an adult-specific form of cytochrome P450 in human livers, and its transcriptional control”, Eur. J. Biochem. 218:585-595 (1993).
Barwick et al, “Trans-species Gene Transfer for Analysis of Glucocorticoid-Inducible Transcriptional Activation of Transiently Expressed Human CYP3A4 and Rabbit CYP3A6 in Primary Cultures of Adult Rat and Rabbit Hepatocytes”, Molec. Pharmacol. 50:10-16 (1996).
Fields et al, “A novel genetic system to detect protein-protein interactions”, Nature 340:245-246 (1989).
Forman et al, “Hypolipidemic drugs, polyunsaturated fatty acids, and eicosanoids are ligands for peroxisome proliferator-activated receptors α and δ”, Proc. Natl. Acad. Sci. USA 94:4312-4317 (1997).
Luckow et al, “CAT constructions with multiple unique restriction sites for the functional analysis of eukaryotic promoters and regulatory elements”, Nucleic Acids Research 15(13):5490 (1987).
Kliewer et al, “An Orphan Nuclear Receptor Activated by Pregnanes Defines a Novel Steroid Signaling Pathway”, Cell 92:73-82 (1998).
Smith et al, “A novel nuclear receptor superfamily member in Xenopus that associates with RXR, and shares extensive sequence similarity to the mammalian vitamin D3 receptor”, Nucleic Acids Research 22(1):66-71 (1994).
Nagpal et al, RAR-β4, a retinoic acid receptor isoform is generated from RAR-β2 by alternative splicing and usage of a CUG initiator codon, Proc. Natl. Acad. Sci. USA 89:2718-2722 (1992).
Quattrochi et al, “A Novel cis-Acting Element in a Liver Cytochrome P450 3A Gene Confers Synergisitc Induction by Glucocorticoids plus Antiglucocorticoids”, The Journal of Biological Chemistry 270(48):28917-28923 (1995).
Huss et al, “Dexamethasone responsiveness of a major glucocorticoid-inducible CYP3A gene is mediated by elements unrelated to a glucocorticoid receptor binding motif”, Proc. Natl. Acad. Sci. USA 93:4666-4670 (1996).
Molowa et al, “Complete cDNA sequence of a cytochrome P-450 inducible by glucocorticoids in human liver”, Proc. Natl. Acad. Sci. USA 83:5311-5315 (1986).
Kocarek et al, “Comparative Analysis of Cytochrome P4503A Induction in Primary Cultures of Rat, Rabbit, And Human Hepatocytes”, Drug Metabolism and Disposition 23(3):415-421 (1995).
Schuetz et al, “Induction of Cytochrome P-450 by Glucocorticoids in Rat Liver”, The Journal of Biological Chemistry 259(3):2007-2012 (1984).
Heuman et al, “Immunochemical Evidence for Induction of a Common Form of Hepatic Cytochrome P-450 in Rats Treated with Pregnenolone-16α-carbonitrile or other Steroidal or Non-Steroidal Agents”, Molecular Pharmacology 21:753-760 (1982).
Schulte-Hermann et al, “Quantitative Structure-Activity Studies on Effects of Sixteen Different Steroids on Growth and Monooxygenases of Rat Liver”, Cancer Research 48:2462-2468 (1988).
Wrighton et al, “Identification of the Cytochrome P-450 Induced by Macrolide Antibiotics in Rat Liver as the Glucocorticoid Responsive Cytochrome P-450p”, Biochemistry 24:2171-2178 (1985).
Hostetler et al, “Coinduction of Multiple Hepatic Cytochrome P-450 Proteins and Their mRNAs in Rats Treated with Imidazole Antimycotic Agents”, Molecular Pharmacology 35:279-285 (1989).
Kocarek et al, “Regulation of Phenobarbital-Inducible Cytochrome P450 2B1/2 mRNA by Lovastatin and Oxysterols in Primary Cultures”, Toxicology and Applied Pharmacology 120:298-308 (1993).
Schuetz et al, “Regulation of Human Liver Cytochromes P-450 in Family 3A in Primary and Continuous Culture of Human Hepatocytes”, Hepatology 18:1254-1262 (1993).
Calleja et al, “The antibiotic rifampicin is a nonsteroidal ligand and activator of the human glucocorticoid receptor”, Nature Medicine 4(1):92-96 (1998).
Krey et al, “Fatty Acids, Eicosanoids, and Hypolipidemic Agents Identified as Ligands of Peroxisome Proliferator-Activator Receptors by Coactivator-Dependent Receptor Ligand Assay”, Molecular Endocrinology 11:779-791 (1997).
Bertilsson et al, “Identification of a human nuclear receptor defines a new signaling pathway for CYP3A induction”, Proc. Natl. Acad. Sci. USA 95:12208-12213 (1998).
Blumberg et al, “BXR, and embryonic orphan nuclear receptor activated by a novel class of endogenous benzoate metabolites”, Genes & Development 12:1269-1277 (1998).
Lehmann et al, “The Human Orphan Nuclear Receptor PXAR Is Activated by Compounds That RegulateCYP3A4Gene Expression and Cause Drug Interactions”, J. Clin. Invest. 102(5):1016-1023 (1998).
Blumberg et al, “SXR, a novel steroid and xenobiotic-sensing nuclear receptor”, Genes & Development 12:3195-3205 (1998).
Jones et al, “The Pregnane X Receptor: A Promiscuous Xenobiotic Receptor That Has Diverged during Evolution”, Molecular Endocrinology 14(1):27-39 (2000).
Kliewer et al, “Transcriptional Regulation of Energy Balance by the PPARs”, 9thInternational CBT Symposium on Nuclear Steroid and Orphan Receptors, Oral Presentation, Oct. 12-15, 1997, Huddinge, Sweden.
Moore et al., “St. John's Wort Induces Hepatic Drug Metabolism Through Activation of the Pregnane X Receptor” Proc. Nat'l Acad. Sci. U.S.A., 97(13):7500-7502 (2000) XP002200518.
Paolini et al. “Bile Acid Structure and Selective Modulation of Murine Hepatic Cytochrome Enzymes” Hepatology, 30(3):730-739 (1999) XP008003770.
Paolini et al. “Mechanism for the Prevention of Cholestasis Involving Cytochrome P4503A overexpression” J. Invest. Med. 48(1):49-59 (2000) XP00803771.
Jones Stacey A.
Kliewer Steven A.
Willson Timothy M.
Conger Michael M.
Pak Michael
SmithKline Beecham Corporation
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