Pregnane derivatives as immunomodulators

Details Pregnane derivatives as immunomodulators Pregnane derivatives as immunomodulators

1990-05-17

1993-03-09

Waddell, Frederick E.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Cyclopentanohydrophenanthrene ring system doai

514177, 514885, A61K 3156

Patent

active

051927551

ABSTRACT:
The invention provides novel pregnane derivatives having the formula: ##STR1## wherein X=F, Cl or Br; R.sub.1 =F or Cl; R.sub.2 =H(.beta.OH) or O; R.sub.3 =alkyl(1-4 C); R.sub.4 =alkyl(1-4 C); and the dotted line indicates the optional presence of a double bond.
The novel compounds have been found to possess immunomodulating properties.

REFERENCES:
patent: 3162630 (1964-12-01), Morand
patent: 3483236 (1969-12-01), Schaub
patent: 3520908 (1970-07-01), Hewett et al.
patent: 3531503 (1970-09-01), Cereghetti et al.
patent: 4678609 (1987-07-01), Engels
patent: 4839282 (1989-06-01), Weber et al.
Steroid Reactions (1963), p. 202; Djerassi.
Chemical Abstracts, Abstract No. 47795p, vol. 78, p. 278 (Feb. 1973).
Max Samter, M.D., Editor, Immunological Diseases, "86. Pharmacological Immunosuppression", vol. II, pp. 1522-1533 (1978).

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