Pregnane and cholane steroids as neurochemical initiators of cha

Details Pregnane and cholane steroids as neurochemical initiators of cha Pregnane and cholane steroids as neurochemical initiators of cha

1995-08-03

1999-11-30

Dees, Jose' G.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Cyclopentanohydrophenanthrene ring system doai

514170, 514177, 514178, 514179, 514181, 514182, 552532, 552533, 552536, 552537, 552538, 552553, 552554, 552555, 552583, 552601, 552602, 552604, 552605, 552606, 552607, 552608, 552609, A61K 3156, C07J 500, C07J 900, C07J 1300

Patent

active

059943335

ABSTRACT:
The invention relates to a method of altering hypothalamic function in an individual. The method comprises nasally administering a human vomeropherin, e.g. a pregnane or cholane steroid, or a pharmaceutical composition containing a vomeropherin, such that the vomeropherin binds to a specific neuroepithelial receptor. The steroid or steroids is/are preferably administered in the form of a pharmaceutical composition containing one or more pharmaceutically acceptable carriers. Other embodiments of the invention include pharmaceutical compositions containing the steroids.

REFERENCES:
Li, Ruisheng, et al., "Two polyhydroxylated steroids from the Chinese soft coral Litophyton arboreum," Steriods, (Aug. 1994) vol. 59, pp. 503-505.
Terasawa, T., et al., "Convenient Preparative Routes to 19-Hydroxy, 19-Oxo-, 19-Oic, and 19 Nor-Deoxycorticosterone," Tetrahedron (1986), vol. 42, No. 2, pp. 537-545.
Garcia-Velasco et al., Aesth. Plast. Surg. 19:451-454 (1995).
Axel, Scientific American, Oct. 1995 pp. 154-159.
Bovicelli et al., "Oxyfunctionalization of steroids by dioxirances site and stereoselective C14 and C17 hydroxylation of pregnane and androstane steroids". Tetrahedron Lett., vol. 34(38), 6103-6104, 1993.
Cheng et al., "Tandem mass spectrometry: structural and stereochemical information from steroids". J. Am. Chem. Soc., vol. 105(6), 1510-1513, 1983.

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