Preformed carboxylated active ester for labeling biomolecules

Details Preformed carboxylated active ester for labeling biomolecules Preformed carboxylated active ester for labeling biomolecules

2005-02-08

2005-02-08

Wilson, James (Department: 1623)

Organic compounds -- part of the class 532-570 series

Organic compounds

Unsubstituted hydrocarbyl chain between the ring and the -c-...

C540S470000, C540S476000, C549S470000, C534S010000

Reexamination Certificate

active

06852854

ABSTRACT:
The present invention is directed, in general, to a method for making high yields of functionalized cyclic or acyclic tertiary amine-containing compounds, termed active esters, the functionalized compounds themselves, and diagnostic or therapeutic systems incorporating such compounds. Ester groups are attached to all but one of its Nitrogen atoms of the tertiary amine-containing compound. Therefore, an active agent, in the presence of coupling agent, attaches to the remaining amine via a carboxylate group attached to the amine, to produce high yields of the active ester. The active ester is then combined with a biomolecule, to produce high yields of a bioconjugated product. A metal ion may be chelated to the bioconjugated product to produce a chelating agent for use in either diagnostic or therapeutic applications.

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