Liquid purification or separation – With means to add treating material – Chromatography
Reexamination Certificate
2008-06-24
2008-06-24
Therkorn, Ernest G (Department: 1797)
Liquid purification or separation
With means to add treating material
Chromatography
C210S348000, C210S502100, C210S512100
Reexamination Certificate
active
07390403
ABSTRACT:
The present invention is to a prefilter for purification systems such as affinity chromatography columns and ultrafiltration systems. The prefilter, positioned upstream of the system inlet, reduces the presence of non-specific binding (NSB) species that enter the system, thereby extending the yield, capacity and lifetime of the system. Suitable agents include but are not limited to hydrophobic entities; lipophilic entities; activated carbon; charged cation or anion entities; ligands; particles such as fumed silica, glass, controlled pore glass or derivitized version of each; silica or silicates; and combinations thereof. The material(s) can be incorporated into a variety of media such as fibers, beads, membranes and the like and then incorporated into a variety of device designs including lenticular pads, depth filters, bead containing columns, spiral wound devices, TFF devices and the like.
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Yigzaw, et al., “Exploitation of the Adsorption Properties of Depth Filters to Remove Host Cell Protein Contaminants in Downstream Processing,” Presentation: ACS National Meeting, Session on Bioprocess Integration, Mar. 13-17, 2005.
Millipore Corporation
Therkorn Ernest G
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