Preferential induction of electrically mediated cell death from

Details Preferential induction of electrically mediated cell death from Preferential induction of electrically mediated cell death from

1996-01-03

1998-02-17

Kamm, William E.

Surgery

Miscellaneous

Methods

600 14, 607 2, A61N 100

Patent

active

057182469

ABSTRACT:
A method for inducing necrosis in susceptible malignant cells, comprises two general steps. First, positioning a collection of cells containing the susceptible malignant cells within a treatment domain, wherein the treatment domain is subjected to a non-ionizing radiation field. Second, pulsing said non-ionizing radiation field with a frequency and an intensity selected to produce necrosis in the susceptible malignant cells by creating a transmembrane potential that causes an increase in ionic diffusion in the susceptible malignant cells or generates reversible electroporation of the susceptible malignant cells. Though both malignant and non-malignant cells may be reversibly porated, it is posited that many forms of cancer will be more vulnerable to the subject procedure.

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