Chemistry: analytical and immunological testing – Lipids – triglycerides – cholesterol – or lipoproteins
Reexamination Certificate
2004-12-24
2008-07-15
Wallenhorst, Maureen M (Department: 1797)
Chemistry: analytical and immunological testing
Lipids, triglycerides, cholesterol, or lipoproteins
C436S063000, C436S086000
Reexamination Certificate
active
07399638
ABSTRACT:
The present invention provides a prediction method for lipidosis caused by a compound, which includes detecting (a) phenylacetylglycine and/or phenylacetylglutamine, or an optionally chosen metabolic intermediate in the metabolic pathway from phenylalanine to phenylacetylglycine or phenylacetylglutamine, and (b) hippuric acid or an optionally chosen metabolic intermediate in the metabolic pathway from phenylalanine to hippuric acid, in a sample collected from a mammal receiving the compound or a mammalian cell or tissue culture exposed to the compound, and predicting the compound's potential for inducing lipidosis with the quantitative ratio of the two as the index. The present invention also provides a diagnostic method for lipidosis and diseases related thereto, including detecting (a) and (b) above in a sample collected from a mammal, and making a diagnosis with the quantitative ratio of the two as the index.
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Horinouchi Akira
Mori Ikuo
Murabayashi Mika
Colin David G.
Edwards Angell Palmer & & Dodge LLP
Piffat Kathryn A.
Takeda Pharmaceutical Company Limited
Wallenhorst Maureen M
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