Predicting post-treatment survival in cancer patients with...

Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving nucleic acid

Reexamination Certificate

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C435S091100, C435S091200

Reexamination Certificate

active

07745134

ABSTRACT:
This invention provides a method for predicting the post-treatment survival prospect of a cancer patient based on the expression level(s) of microRNAs hsa-miR137, hsa-miR372, hsa-miR182*, hsa-miR221, and hsa-let-7a in that cancer patient.

REFERENCES:
patent: 2004/0152112 (2004-08-01), Croce
patent: 2005/0262577 (2005-11-01), Guelly
patent: 2005/0272067 (2005-12-01), Macina
patent: 2006/0078913 (2006-04-01), Macina
patent: 2006/0105360 (2006-05-01), Croce
patent: 2006/0165659 (2006-07-01), Croce
patent: 2007/0065844 (2007-03-01), Golub
Yu et al., “MicroRNA Signature Predicts Survival and Relapse in Lung Cancer,” Cancer Cell, Jan. 2008, vol. 13, pp. 48-57.
Bandres, E., et al., “Identification by Real-time PCR of 13 mature microRNAs differentially expressed in colorectal cancer and non-tumoral tissues”. Molecular Cancer. Jul. 19, 2006, vol. 5, pp. 29-38; abstract; p. 1179, para 7.
Voorhoeve, P.M., et al., “A genetic Screen Implicates miRNA-372 and miRNA-373 as Oncogenes in Testicular Germ Cell Tumors”. Cell.Mar. 24, 2006, vol. 124, pp. 1169-1181; Table I; p. 36, para 5.

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