Precursor to nucleic acid probe

Details Precursor to nucleic acid probe Precursor to nucleic acid probe

1987-07-13

1988-06-28

Schwartz, Richard A.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carboxylic acids and salts thereof

C07C10344

Patent

active

047540656

ABSTRACT:
Nucleic acids may be labeled by intercalating the alkylating intercalation moiety of a labeling reagent into a partially double-stranded nucleic acid to form a complex and activating the complex to cause covalent bonding between the reagent and the nucleic acid. Preferably, the labeled nucleic acid is a hybridization probe for detecting nucleic acid sequences capable of hybridizing with a hybridizing region of the nucleic acid. Also preferably the label moiety is non-radioactive. The labeling reagent is of the formula:

REFERENCES:
patent: 4124598 (1978-11-01), Hearst et al.
patent: 4194070 (1980-03-01), Marquis et al.
patent: 4582789 (1986-04-01), Sheldon et al.
patent: 4617261 (1986-10-01), Sheldon et al.
W. Saffran et al., Proc. Natl. Acad. Sci. USA, 79, 4594-4598 (1982).
D. Schwartz et al., CSH Laboratory Symposium XLVII.

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