Organic compounds -- part of the class 532-570 series – Organic compounds – Carboxylic acids and salts thereof
Patent
1987-07-13
1988-06-28
Schwartz, Richard A.
Organic compounds -- part of the class 532-570 series
Organic compounds
Carboxylic acids and salts thereof
C07C10344
Patent
active
047540656
ABSTRACT:
Nucleic acids may be labeled by intercalating the alkylating intercalation moiety of a labeling reagent into a partially double-stranded nucleic acid to form a complex and activating the complex to cause covalent bonding between the reagent and the nucleic acid. Preferably, the labeled nucleic acid is a hybridization probe for detecting nucleic acid sequences capable of hybridizing with a hybridizing region of the nucleic acid. Also preferably the label moiety is non-radioactive. The labeling reagent is of the formula:
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W. Saffran et al., Proc. Natl. Acad. Sci. USA, 79, 4594-4598 (1982).
D. Schwartz et al., CSH Laboratory Symposium XLVII.
Levenson Corey H.
Mullis Kary B.
Cetus Corporation
Halluin Albert P.
Hasak Janet E.
Schwartz Richard A.
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