Precursor of a C-terminal amidated calcitonin

Details Precursor of a C-terminal amidated calcitonin Precursor of a C-terminal amidated calcitonin

1990-11-05

1993-10-12

Schwartz, Richard A.

Chemistry: molecular biology and microbiology

Micro-organism, per se ; compositions thereof; proces of...

Bacteria or actinomycetales; media therefor

435 694, 4351723, 4353201, 536 2351, C12N 1516, C12N 1570, C12N 121

Patent

active

052524825

ABSTRACT:
A precursor of a C-terminal amidated peptide represented by the general formula P-X-Gly-Y.sub.n, wherein P is a peptide residue. X is an amino acid residue the C terminal of which (on the Gly side) can be converted in vivo to a --CONH.sub.2 group. Gly is a glycine residue, Y is a basic amino acid residue, n is an interger of 2 to 4 and a further amino acid residue other than Y or a peptide residue may be attached to Y.sub.n, is produced by a gene engineering technology. The precursor exhibits in vivo physiological activity like the C-terminal amidated peptide.

REFERENCES:
patent: 4321365 (1982-05-01), Wu et al.
patent: 4366246 (1982-12-01), Riggs
patent: 4375514 (1983-03-01), Siewert et al.
Goodman et al., Biochem Biophys Res Comm, vol. 91(3) 1979, pp. 932-938, "Cell-free translation of messenger RNA coding for a precursor of human calcitonin".
Allison et al., Biochem J., vol. 199, 1981, pp. 725-731, "The construction and partial characterization of plasmids containing complementary DNA sequence to human calcitonin polyprotein".
Amara et al., PNC Natl Acad Sci, vol. 77 (8), pp. 4444-4448, 1981, "Characterization of calcitonin mRNA".
Craig et al., Nature, vol. 295, Jun. 28, 1982, pp. 345-347, "Partial nucleotide sequence of human calcitonin precursor mRNA identities flanking cryptic peptides".

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