Surgery – Diagnostic testing – Detecting nuclear – electromagnetic – or ultrasonic radiation
Reexamination Certificate
2005-10-18
2005-10-18
Jaworski, Francis J. (Department: 3737)
Surgery
Diagnostic testing
Detecting nuclear, electromagnetic, or ultrasonic radiation
C600S500000
Reexamination Certificate
active
06955648
ABSTRACT:
The present invention relates generally to systems and methods for assessing blood flow in blood vessels, for assessing vascular health, for conducting clinical trials, for screening therapeutic interventions for adverse effects, and for assessing the effects of risk factors, therapies and substances, including therapeutic substances, on blood vessels, especially cerebral blood vessels, all achieved by measuring various parameters of blood flow in one or more vessels and analyzing the results in a defined matter. The relevant parameters of blood flow include mean flow velocity, systolic acceleration, and pulsatility index. By measuring and analyzing these parameters, one can ascertain the vascular health of a particular vessel, multiple vessels and an individual. Such measurements can also determine whether a substance has an effect, either deleterious or advantageous, on vascular health. In one of many embodiments, the present invention further provides an expert system for achieving the above.
REFERENCES:
patent: 4608993 (1986-09-01), Albert
patent: 4835690 (1989-05-01), Gangarosa et al.
patent: 5052395 (1991-10-01), Burton et al.
patent: 5070880 (1991-12-01), Gomez et al.
patent: 5109868 (1992-05-01), Smith et al.
patent: 5287753 (1994-02-01), Routh et al.
patent: 5353793 (1994-10-01), Bornn
patent: 5379770 (1995-01-01), Van Veen
patent: 5388583 (1995-02-01), Ragauskas et al.
patent: 5447939 (1995-09-01), Glasky et al.
patent: 5558092 (1996-09-01), Unger et al.
patent: 5579774 (1996-12-01), Miller et al.
patent: 5628321 (1997-05-01), Scheib et al.
patent: 5664109 (1997-09-01), Johnson et al.
patent: 5749831 (1998-05-01), Baker
patent: 5845253 (1998-12-01), Rensimer et al.
patent: 5853005 (1998-12-01), Scanlon
patent: 5868676 (1999-02-01), McCabe et al.
patent: 6047203 (2000-04-01), Sackner et al.
patent: 6056690 (2000-05-01), Roberts
patent: 6117911 (2000-09-01), Grainger et al.
patent: 6151581 (2000-11-01), Kraftson et al.
patent: 6154726 (2000-11-01), Rensimer et al.
patent: 6235706 (2001-05-01), Gould et al.
patent: 6258032 (2001-07-01), Hammesfahr
patent: 6316403 (2001-11-01), Pinsky et al.
patent: 6328694 (2001-12-01), Michaeli
patent: 6381482 (2002-04-01), Jayaraman et al.
patent: 6551252 (2003-04-01), Sackner et al.
Albers, G.W.,Choice of Endpoints in Antiplatelet Trials, Which Outcomes Are Most Relevant to Stroke Patients7,Neurology, Mar., 2000, vol. 54, No. 5, pp. 1022-1028.
Alexandrov, A.V. et al., “Transcranial Doppler: An Overview of its Clinical Applications,” The Internet Journal of Emergency and Intensive Care Medicine (2000), vol. 4, No. 1, (found at www.ispub.com).
Bauernschmitt, R. et al., “Simulation of Baroreflex Control in a Pulsatile Mathematical Model of the Human Arterial Circulation,” Computers in Cardiology (1999) 26, pp. 229-232.
Cevenini, G. et al., “A Neural Network Improves the Classification of High-Risk Intensive Care Patients,” 18thAnnual International Conference of the IEEE Engineering in Medicine and Biology Society, 1996, Amsterdam, pp. 2207-2208.
Charniak, E. et al.,Artificial Intelligence Programming,1980, Preface, (pp. ix-xii), Lawrence Erlbaum Associate, Publishers, Hillsdale, NJ.
Doblar, D.D., “Cerebrovascular Assessment of The High-Risk Patient: The Role of Transcranial Doppler Ultrasound,” J Cardiothorac Vasc Anesth, Jan. 1996 vol. 10(1):3-14 (National Library of Medicine Abstract).
Fritz, W. et al., “Transcranial Doppler Sonographic Identification of a Subgroup of Patients with Normal Pressure Hydrocephalus with Coexistent Vascular Disease and Treatment Failure,” Neurosurgery (1989), vol. 25, No. 5, pp. 777-780.
Guyot, JP, “Snoring and Obstructive Sleep Apnea Syndrome: A Controversial Issue,” S. Karger Medical and Scientific Publishers, Nov. 2002, Basel, Switzerland (BOOK).
Hays, A.M. et al., “Quantitative Phase Contrast Images To Quantitate Flow in A Rat Model Of Microgravity,” Aviat Space Environ Med, Mar. 1999 70(3 Pt. 1): 225-9 (National Library of Medicine Abstract).
Hussian, M.A. et al., “Microcirculation and Hemorheology in Cerebrovascular Accidents and Hypertension: An Application of Laser Doppler Flowmetry,” Proceedings of the 16thAnnual International Conference of the IEEE Engineering in Medicine and Biology Society, Engineering Advances: New Opportunities for Biomedical Engineers, Nov. 3-6, 1994, vol. 16, Baltimore, MD.
Johnson, T. et al., “Phantom of the Night: Overcome Sleep Apnea Syndrome and Snoring—Win Your Hidden Struggle to Breathe, Sleep, and Live”, New Technology Pub. Inc., 1996, Cambridge, Mass.
Landers S.J., “Beyond Cholesterol: New Uses For Statins—This Class of Drugs May Offer Potential To Treat A Range of Conditions -From Osteoporosis to Alzheimer's.” Amednews.com (Jun. 18, 2001), from AMA-ASSN.ORG.
Lee, E.J. et al., “Cerebral Blood Flow Velocity and Vasomotor Reactivity Before and After Shunting Surgery in Patients With Normal Pressure Hydrocephalus,” Acta Neurochir (Wien), 1998; 140(6): 599-604: discussion 604-5,, (National Library of Medicine Abstract).
Lipitor, FDA approved product information.
Lutsep, H.L., et al., “Association of Intracranial Stenosis with Cortical Symptoms or Signs,”Neurology(2000), vol. 55, pp. 716-718.
Morgenlander, J.C. et al., “Transcranial Doppler Sonography to Monitor Cerebral Vasculitis,” J Rheumatol, Mar. 1996, vol. 23(3):561-3, (National Library of Medicine Abstract).
Nicolet Vascular, Nicolet Transcranial Doppler Tutorial Workbook, Your Diagnostic Choice.
Nonoshita-Karr, L. et al., “Transcranial Doppler Sonography Freshan Examination Techniques,” The Journal of Vascular Technology (2000) vol. 24, No. 1, pp. 9-16.
Patlak, M., “When Can Statins Be Too Much Of A Good Thing?”, ACP-ASIM Observer, Mar. 2002.
Pepys, M.B. et al., “Targeted Pharmacological Depletion of Serum Amyloid P Component For Treatment of Human Amyloidosis,” Nature, vol. 417, May 16, 2002, pp. 254-259.
Rinnooy Kan, A.H.G.,Machine Scheduling Problems,1976, Introduction, Ch. 7—Concluding Remarks, pp. 1-4 and 131-142, Martinus Nijhoff, The Hague.
Sacerdoti, E.D.,A Structure for Plans and Behavior,1977, Introduction, Ch 7—Summary and Conclusions, pp. 1-2 and 103-111, Elsevier North-Holland, Inc. New York, New York.
Schank, R.C. et al.,Inside Computer Understanding: Five Programs Plus Miniatures,1981, Ch 1—Our Approach to Artificial Intelligence, pp. 1-40, Lawrence Erlbaum Associates, Hillsdale, New Jersey.
Schank, R.C. et al.,Scripts, Plans, Goals and Understanding—An Inquiry Into Human Knowledge Structure,1977, Ch 1 & 2, pp. 1-35, Lawrence Erlbaum Associates, Hillsdale, New Jersey.
Seljeflot, I. et al. , “Reduced Expression of Endothelial Cell Markers After 1 Year Treatment With Simvastatin and Atorvastatin in Patients With Coronary Heart Disease,” Atherosclerosis, May 2002, vol. 162, Issue 1, pp 179-185 (abstract).
Ursino, M. et al., “A Mathematical Study of Some Biomechanical Factors Affecting the Oscilometric Blood Pressure Measurement,” IEEE Transactions on Biomedical Engineering, Aug. 1996, vol. 43, No. 8, pp. 761-778.
Wang, Z. G. et al., “A Microprocessor-Based Multi-Functional Therapeutic Device for Treatment of Patients with Cerebrovascular Diseases,” IEEE Instrumentation and Measurement Technology Conference, May 18-21, 1998, St. Paul, MN, pp. 239-242.
Wong, T.Y. et al., “Retinal Arteriolar Narrowing and Risk of Coronary Heart Disease in Men and Women—The Atherosclerosis Risk in Communities Study,” JAMA, Mar. 6, 2002, vol. 287, No. 9, pp. 1153-1159.
Wong, T.Y. et al., “Retinal Arteriolar Narrowing and Risk of Diabetes Mellitus in Middle-aged Persons,” JAMA, May 10, 2002, vol. 287, No. 19, pp. 2528-2533.
Zar, J.H.,Biostatistical Analysis,Second Addition, 1984, pp. 153-161, Prentice-Hall, Inc., Englewood Cliffs, NJ.
Clayman, C.B., et al, The American Medical Asso
Crutchfield Kevin E.
Davidson John B.
Fitall Simon
Mozayeni B. Robert
Hogan & Hartson LLP
Jaworski Francis J.
New Health Sciences, Inc.
LandOfFree
Precision brain blood flow assessment remotely in real time... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Precision brain blood flow assessment remotely in real time..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Precision brain blood flow assessment remotely in real time... will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-3467840