Preblend of microcrystalline cellulose and lactase for making ta

Details Preblend of microcrystalline cellulose and lactase for making ta Preblend of microcrystalline cellulose and lactase for making ta

1995-06-29

2000-05-02

Naff, David M.

Chemistry: molecular biology and microbiology

Enzyme , proenzyme; compositions thereof; process for...

Stablizing an enzyme by forming a mixture, an adduct or a...

424 9461, 424464, 424465, 435179, 435200, 435207, C12N 996, C12N 1112, A61K 3847, A61K 920

Patent

active

06057139&

ABSTRACT:
A preblend for making lactase tablets is prepared containing about 1-99% (preferably about 20-60%) by weight lactase and about 1-99% (preferably about 40-80%) by weight microcrystalline cellulose. Lactase used in the preblend may be in combination with up to about 4 parts (preferably about 0.5-2 parts) by weight cutting agent such as sugars, starches, cellulose, and inorganic salts for each part by weight lactase. About 0.5-4% by weight lubricant such as magnesium stearate may be present in the preblend. A preferred preblend contains about 9.6 weight percent lactase and about 90 weight percent microcrystalline cellulose. Another preferred preblend contains about 9.6 weight percent lactase, about 30.0 weight percent microcrystalline cellulose and about 59.4 weight percent mannitol. Each preblend may also contain magnesium stearate. A preferred lactase is from Aspergillus oryzae and the microcrystalline cellulose preferably has an average particle size of about 20-200 .mu.m.

REFERENCES:
patent: 3718739 (1973-02-01), Cayle
patent: 3954979 (1976-05-01), Bowman
patent: 4034035 (1977-07-01), Schwartz et al.
patent: 4079125 (1978-03-01), Sipos

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