Pre-S gene coded peptide hepatitis B immunogens and synthetic li

Details Pre-S gene coded peptide hepatitis B immunogens and synthetic li Pre-S gene coded peptide hepatitis B immunogens and synthetic li

1993-03-15

1996-10-15

Warden, Jill

Chemistry: natural resins or derivatives; peptides or proteins;

Peptides of 3 to 100 amino acid residues

25 or more amino acid residues in defined sequence

530345, 530402, 530403, 530404, 530325, 530326, 530327, 530810, 4241841, 4241851, 4242041, 4242341, 4242651, 4242751, 4242781, 4242271, A61K 3800, A61K 3900, A61K 4500, C17K 500

Patent

active

055655483

ABSTRACT:
A hepatitis B vaccine containing a peptide with an amino acid chain of at least six consecutive amino acids within the pre-S gene coded region of the envelope of hepatitis B virus. The vaccine being free of an amino acid sequence corresponding to the naturally occurring envelope proteins of hepatitis B virus and a physiologically acceptable diluent. The peptide being free or linked to a carrier. The carrier being a conventional carrier or a novel carrier including a lipid vesicle stabilized by cross-linking and having covalently bonded active sites on the outer surface thereon. Such novel carrier being useful not only to link the novel peptide containing an amino acid chain with amino acids within the pre-S gene coded region of the surface antigen of hepatitis B virus, but can also be used to bind synthetic peptide analogues of other viral proteins, as well as bacterial, allergen and parasitic proteins of man and animals. The peptides of the invention can be utilized in diagnostics for the detection of antigens and antibodies.

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