Pre-organized tricyclic integrase inhibitor compounds

Details Pre-organized tricyclic integrase inhibitor compounds Pre-organized tricyclic integrase inhibitor compounds

2007-08-07

2007-08-07

Seaman, Margaret D. (Department: 1625)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

C546S023000, C546S084000

Reexamination Certificate

active

10687373

ABSTRACT:
Tricyclic compounds according to the structure below, protected intermediates thereof, and methods for inhibition of HIV-integrase are disclosed.A1and A2are moieties forming a five, six, or seven membered ring. L is a bond or a linker connecting a ring atom of Ar to N. X is O, S, or substituted nitrogen. Ar is aryl or heteroaryl. Q is N,+NR, or CR4. The aryl carbons may be independently substituted with substituents other than hydrogen. The compounds may include prodrug moieties covalently attached at any site.

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