Pre-conditioning against cell death

Details Pre-conditioning against cell death Pre-conditioning against cell death

2006-05-16

2006-05-16

Meller, Michael (Department: 1655)

Drug, bio-affecting and body treating compositions

Whole live micro-organism, cell, or virus containing

Animal or plant cell

Reexamination Certificate

active

07045124

ABSTRACT:
Apoptosis and/or necrosis related disorders in the mammalian body, namely radiation exposure disorders, chemical exposure and ingestion disorders, neurological disorders and physical trauma disorders, are treated, and their onset is counteracted by preconditioning, by extracting from the mammalian body an aliquot of blood, subjecting the extracted aliquot, ex vivo, to an oxidative stressor such as exposure to ozone gas, a temperature stressor, i.e. temperatures above or below body temperatures, and ultraviolet light, and re-injecting the treated blood aliquot into the mammalian body. The treatment ha the effect of decreasing apoptosis
ecrosis in the body, and of pre-conditioning the body better to withstand subsequently encountered apoptosis-inducing events.

REFERENCES:
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Ganelina et al., “Therapy of Severe Steno Cardias by UV Irradiation of the Blood and Some Action Mechanisms of This Therapy”, Folia Haematologica, DE, Akademische Verlagsgesellschaft, Leipzig, vol. 109, No. 3, 1982, pp. 470-482, Abstract Only.
Cooke, et al., “Treatment of severe Raynaud's syndrome by injection of autologous blood pretreated by heating, ozonation and exposure to ultraviolet light (H-O-U) therapy”, International Angiology, Dec. 1997, pp. 250-254, United Kingdom.

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