Pre-adipose cell lines

Details Pre-adipose cell lines Pre-adipose cell lines

2007-11-13

2007-11-13

Kaushal, Sumesh (Department: 1633)

Chemistry: molecular biology and microbiology

Animal cell, per se ; composition thereof; process of...

C435S069100, C435S320100, C435S366000, C435S377000, C435S455000, C435S467000

Reexamination Certificate

active

10348480

ABSTRACT:
This invention relates to new immortalized human pre-adipose cell lines capable of differentiating into adipose cells and methods of obtaing the immortalized cells. In particular, the present invention pertains to immortalized pre-adipocyte cell lines derived from white adipose tissue and methods of producing the cell lines. The immortalized pre-adipocyte cells are capable of maturing into immortalized white adipose cells useful in developing drugs, food ingredients and supplements against obesity, diabetes and cardiovascular diseases.

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Kolarova P., et al.: “Conditional immortalization of white adipocytes using SV40 large T-antigen from the transgenic mouse.” European Journal of Cell Biology , vol. 74, No. suppl. 47, 1997, p. 87. XP000990293.
Thomas M., et al.: “Formation of functional tissue from transplanted adrenocortical cells expressing telomerase reverse transcriptase.” Nature Biotechnology, vol. 18, No. 1, Jan. 2000-2001, pp. 39-42, XP002185530.

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