Organic compounds -- part of the class 532-570 series – Organic compounds – Carboxylic acid esters
Reexamination Certificate
2005-08-30
2005-08-30
Tsang, Cecilia J. (Department: 1625)
Organic compounds -- part of the class 532-570 series
Organic compounds
Carboxylic acid esters
C560S119000, C560S188000, C435S125000, C435S169000
Reexamination Certificate
active
06936731
ABSTRACT:
The present invention provides pravastatin sodium substantially free of pravastatin lactone and epiprava, the C-6 epimer of pravastatin. The present invention further provides a novel process for recovering pravastatin sodium from a fermentation broth in such high purity. The process includes the stages of forming an solution of the compound by extraction, obtaining an ammonium salt of pravastatin from the solution, purifying the ammonium salt of the compound and transposing the salt of the compound to pravastatin sodium.
REFERENCES:
patent: 4346227 (1982-08-01), Terahara et al.
patent: 5202029 (1993-04-01), Haytko et al.
patent: 5942423 (1999-08-01), Demain et al.
patent: 6695969 (2004-02-01), Grahek et al.
patent: WO 92/16276 (1992-10-01), None
patent: WO 99/42601 (1999-08-01), None
patent: WO 00/17182 (2000-03-01), None
patent: WO0017182 (2000-03-01), None
Merck Index, 11thEdition, p. 1222.
Deak Lajos
Forgacs Ilona
Keri Vilmos
Nagyne Arvai Edit
Szabo Csaba
Reyes Hector
TEVA Gyógyszergyár Részvénytársasá
Tsang Cecilia J.
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