Pravastatin pharmaceuatical compositions having good stability

Details Pravastatin pharmaceuatical compositions having good stability Pravastatin pharmaceuatical compositions having good stability

1991-05-20

1993-01-19

Page, Thurman K.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Tablets, lozenges, or pills

424464, 424489, 514510, 514548, 514970, 560119, A61K 914, A61K 920

Patent

active

051805898

ABSTRACT:
A pharmaceutical composition is provided which has excellent stability, when dispersed in water has a pH of at least about 9, and includes a medicament which is sensitive to a low pH environment such as pravastatin, one or more fillers such as lactose and/or microcrystalline cellulose, one or more binders, such as microcrystalline cellulose (dry binder) or polyvinylpyrrolidone (wet binder), one or more disintegrating agents such as croscarmellose sodium, one or more lubricants such as magnesium stearate and one or more basifying agents such as magnesium oxide.

REFERENCES:
patent: 3865935 (1975-02-01), Amann
patent: 3891755 (1975-06-01), Mehta
patent: 3983140 (1976-09-01), Endo et al.
patent: 4342767 (1982-08-01), Albers-Schonberg et al.
patent: 4346227 (1982-08-01), Terahara et al.
patent: 4609675 (1986-09-01), Franz
patent: 4681759 (1987-07-01), Porubcan
patent: 4755385 (1988-07-01), Etienne et al.
patent: 5030447 (1991-07-01), Joshi et al.

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