Pradimicin derivatives

Details Pradimicin derivatives Pradimicin derivatives

1990-09-28

1997-12-09

Peselev, Elli

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

514 25, 514 27, 536 64, 536 172, 536 168, 536 181, A61K 3170, C07H 1524

Patent

active

056960964

ABSTRACT:
The present invention relates to new antifungal compounds having the formula ##STR1## wherein R.sup.1 is hydrogen, methyl, or hydroxymethyl; R.sup.2 and R.sup.3 are independently selected from the group consisting of hydrogen and C.sub.1-5 alkyl; and R.sup.4 is selected from the group consisting of .beta.-L-xylosyl, .beta.-D-ribosyl, .alpha.-L-arabinosyl, .beta.-D-chinovosyl, .beta.-D-fucosyl, and .beta.-D-glucosyl; with the proviso that when R.sup.1 is methyl or hydroxymethyl, and one of R.sup.2 or R.sup.3 is methyl, R.sup.4 is not .beta.-D-glucosyl; or a pharmaceutically acceptable salt thereof.

REFERENCES:
patent: 4130709 (1978-12-01), Nagarajan
patent: 4870165 (1989-09-01), Oki et al.
patent: 4960755 (1990-10-01), Nishio et al.
patent: 4973673 (1990-11-01), Sawada

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