Practical, cost-efficient chiral synthesis of dihydrosphingosine

Details Practical, cost-efficient chiral synthesis of dihydrosphingosine Practical, cost-efficient chiral synthesis of dihydrosphingosine

1993-04-05

1996-12-24

Kight, John

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

564463, 564489, C07D30300, C07C21100, C07C20900

Patent

active

055874940

ABSTRACT:
Sphingolipids are involved in the structure of biological membranes. There is a link between sphingolipids and signal transduction. The invention relates to the stereospecific syntheses of dihidrosphingosines using certain chiral epoxides.

REFERENCES:
patent: 5012000 (1991-04-01), Illig et al.
patent: 5430169 (1995-07-01), Boumendjel et al.
J. Org. Chem., vol. 50, issued 1985, Roush et al, "Directed Openings of 2,3-Epoxy Alcohols via Reactions with Isocyanates: Synthesis of (+)-erythro-Dihydrosphingosine", pp. 3752-3757.
Chemical Abstracts, vol. 73, No. 23, issued 1970, Eller et al, "Synthesis of D-erythro Dihydrosphingosine", p. 299, col. 2, abstract No. 14056s, Zh. Org. Khim. 1970, 6(4), pp. 665-668 (Russ).
Chemical Abstracts, vol. 77, No. 30, issued 1972, Zav'yalov et al, "Synthesis of Racemic Erythro-dihydrosphingosine", p. 489, col. 1, absract No. 75357v, Isv. Akad. Nauk SSR, Ser. Khim. 1972 (6), 1445-1446 (Russ).

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