PR/SET-domain containing nucleic acids, polypeptides,...

Details PR/SET-domain containing nucleic acids, polypeptides,... PR/SET-domain containing nucleic acids, polypeptides,...

2005-10-18

2005-10-18

Prouty, Rebecca E. (Department: 1652)

Chemistry: molecular biology and microbiology

Enzyme , proenzyme; compositions thereof; process for...

Transferase other than ribonuclease

C435S015000, C435S320100, C435S069100, C435S325000, C435S252300, C536S023200, C530S350000

Reexamination Certificate

active

06955905

ABSTRACT:
The present invention provides an isolated nucleic acid molecule encoding a PFM/SET polypeptide. Also provided is an isolated nucleic acid molecule encoding a functional fragment of a PFM/SET polypeptide that contains a PR, SET, PRAZ or PKZL domain of a PFM/SET polypeptide of the invention. Further provided by the invention are PFM/SET polypeptides, and functional fragments thereof that contain a PR, SET, PRAZ or PKZL domain of a PFM/SET polypeptide. The invention also provides PFM/SET antibodies, PFM/SET modulatory compounds, and related methods. The molecules of the invention can be used in methods of screening for a compound that modulates PFM/SET polypeptide histone methyltransferase activity and to modulate cell proliferation to prevent or treat proliferative disorders, including cancer. Additionally, the molecules and methods of the invention can be used to diagnose and prognose proliferative disorders.

REFERENCES:
Bork , Genome Research, 10:398-400, 2000.
Seffernick et al. , J. Bacteriol. 183(8):2405-2410, 2001.
Van de Loo et al. , Proc. Natl. Acad. Sci. 92:6743-6747, 1995.
Broun et al. , Science 282:1315-1317, 1998.
Witkowski et al. , Biochemistry 38:11643-11650, 1999.
Arakawa et al., “Identification and characterization of the ARP1 gene, a target for the human acute leukemia ALL1 gene,”Proc. Natl. Acad. Sci. USA95:4573-8 (1998).
Baffa et al., “Involvement of the ALL-1 gene in a solid tumor,”Proc. Natl. Acad. Sci. USA92:4922-6 (1995).
Bannister et al., “Selective recognition of methylated lysine 9 on histone H3 by the HP1 chromo domain,”Nature410:120-124 (2001).
Buyse et al., “The retinoblastoma protein binds to RIZ, a zinc finger protein that shares an epitope with the adenovirus E1A protein,”Proc. Natl. Acad. Sci. USA92:4467-4471 (1995).
Buyse et al., “Physical mapping of the retinoblastoma-interacting zinc finger gene RIZ to D1S228 on chromosome 1p36,”Genomics34:119-121 (1996).
Caldas and Aparicio, “Cell memory and cancer—the story of the trithorax and Polycomb group genes,”Cancer&Metastasis Reviews18:313-29 (1999).
Chadwick et al., “Candidate tumor suppressor RIZ is frequently involved in colorectal carcinogenesis;”Proc. Natl. Acad. Sci. USA97:2662-2667 (2000).
Chesi et al., “The t(4;14) translocation in myeloma dysregulates both FGFR3 and a novel gene, MMSET, resulting in IgH/MMSET hybrid transcripts,”Blood92:3025-34 (1998).
Chittka and Chao, “Identification of a zinc finger protein whose subcellular distribution is regulated by serum and nerve growth factor,”Proc. Natl. Acad. Sci. USA96:10705-10710 (1999).
Connolly et al., “Identification of a region of frequent loss of heterozygosity at 11q24 in colorectal cancer,”Cancer Research59:2806-9 (1999).
Corda et al. “Interaction between Set1p and checkpoint protein Mec3p in DNA repair and telomere functions,”Nature Genetics21:204-8 (1999).
Cardoso et al., “Specific interaction between the XNP/ATR-X gene product and the SET domain of the human EZH2 protein,”Human Molecular Genetics7(4):679-684 (1998).
Cui et al., “Association of SET domain and myotubularin-related proteins modulates growth control,”Nature Genetics18:331-337 (1998).
Devlin et al., “High frequency of chromosome 9 deletion in ovarian cancer: evidence for three tumour-suppressor loci,”British Journal of Cancer73:420-3 (1996).
Djabali et al., “A trithorax-like gene is interrupted by chromosome 11q23 translocations in acute leukaemias,” [published erratum appears inNat. Genet. (1993) 4:431],Nature Genetics2:113-8 (1992).
Du et al., “Hypermethylation in human cancers of the RIZ1 tumor suppressor gene, a member of a histone/protein methyltransferase superfamily,”Cancer Research61:8094-8099 (2001).
Fears et al., “Intergenic splicing of MDS1 and EVII occurs in normal tissues as well as in myeloid leukemia and produces a new member of the PR domain family,”Proc. Natl. Acad. Sci. USA93:1642-1647 (1996).
Fidanza et al., “Double knockout of the ALL-1 gene blocks hematopoietic differentiation in vitro,”Cancer Research56:1179-83 (1996).
GenBank Accession No.: 10257424 (Jan. 7, 2002).
GenBank Accession No.: 13274746 (Mar. 17, 2001).
GenBank Accession No.: 13375635 (Mar. 18, 2001).
GenBank Accession No.: 13628859 (Apr. 16, 2001).
GenBank Accession No.: 18550030 (May 13, 2002).
GenBank Accession No.: 912371.1 (Jul. 26, 1995).
GenBank Accession No.: AA014148 (Jan. 21, 1997).
GenBank Accession No.: AA085455.1 (Aug. 1, 1997).
GenBank Accession No.: AA095564.1 (Oct. 25, 1996).
GenBank Accession No.: AA140269.1 (Feb. 11, 1997).
GenBank Accession No.: AA270924.1 (Mar. 26, 1997).
GenBank Accession No.: AA279563.1 (Aug. 15, 1997).
GenBank Accession No.: AA324539.1 (Apr. 20, 1997).
GenBank Accession No.: AA331245.1 (Apr. 21, 1997).
GenBank Accession No.: AA403165.1 (May 16, 1994).
GenBank Accession No.: AA468023.1 (Aug. 13, 1997).
GenBank Accession No.: AA468074.1 (Aug. 13, 1997).
GenBank Accession No.: AA490433.1 (Aug. 15, 1997).
GenBank Accession No.: AA499407.1 (Jul. 1, 1997).
GenBank Accession No.: AA509936.1 (Jul. 8, 1997).
GenBank Accession No.: AA511711 (Jul. 8, 1997).
GenBank Accession No.: AA624796.1 (Oct. 14, 1997).
GenBank Accession No.: AA635466.1 (Oct. 31, 1997).
GenBank Accession No.: AA639997.1 (Oct. 23, 1997).
GenBank Accession No.: AA667932.1 (Nov. 19, 1997).
GenBank Accession No.: AA716121.1 (Dec. 29, 1997).
GenBank Accession No.: AA759024.1 (Dec. 29, 1998).
GenBank Accession No.: AA807222.1 (Apr. 7, 1998).
GenBank Accession No.: AA884744 (Jan. 4, 1999).
GenBank Accession No.: AA917968 (Jun. 23, 1998).
GenBank Accession No.: AA936703.1 (Jun. 10, 1998).
GenBank Accession No.: AB033057 (Nov. 11, 1999).
GenBank Accession No.: AB051462.1 (Feb. 7, 2001).
GenBank Accession No.: AC005283 (Oct. 7, 2000).
GenBank Accession No.: AC010432.6 (Oct. 24, 2000).
GenBank Accession No.: AC012054 (Oct. 19,1999).
GenBank Accession No.: AC013602.4 (Apr. 25, 2001).
GenBank Accession No.: AC015497 (Apr. 11, 2000).
GenBank Accession No.: AC018740 (Jul. 7, 2000).
GenBank Accession No.: AC025451.5 (Jun. 7, 2001).
GenBank Accession No.: AC092836.4 (May 29, 2002).
GenBank Accession No.: AC118140.3 (Jun. 1, 2002).
GenBank Accession No.: AF086123.1 (Aug. 29, 1998).
GenBank Accession No.: AF274347.1 (Jun. 21, 2000).
GenBank Accession No.: AF274348.1 (Jun. 21, 2000).
GenBank Accession No.: AF275816 (Jun. 23, 2000).
GenBank Accession No.: AF275817 (Jul. 23, 2000).
GenBank Accession No.: AF275818 (Jul. 23, 2000).
GenBank Accession No.: AF276513 (Jun. 26, 2000).
GenBank Accession No.: AF287261 (Jul. 30, 2001).
GenBank Accession No.: AF294278 (Nov. 21, 2000).
GenBank Accession No.: AF319458 (Dec. 12, 2000).
GenBank Accession No.: AF346626 (Apr. 3, 2001).
GenBank Accession No.: AI002388.1 (Jul. 23, 1998).
GenBank Accession No.: AI049009 (Jul. 8, 1998).
GenBank Accession No.: AI092401.1 (Oct. 23, 1998).
GenBank Accession No.: AI242496.1 (Nov. 4, 1998).
GenBank Accession No.: AI278689 (Jan. 28, 1999).
GenBank Accession No.: AI348386.1 (Feb. 13, 1999).
GenBank Accession No.: AI352242.2 (Feb. 13, 1999).
GenBank Accession No.: AI357201.1 (Jan. 6, 1999).
GenBank Accession No.: AI383837.1 (Mar. 28, 1999).
GenBank Accession No.: AI610587.1 (May 13, 1999).
GenBank Accession No.: AI699177.1 (Dec. 16, 1999).
GenBank Accession No.: AI705990.1 (Jun. 3, 1999).
GenBank Accession No.: AI816535.1 (Jul. 9, 1999).
GenBank Accession No.: AI879547.1 (Aug. 23, 1999).
GenBank Accession No.: AI887341.1 (Sep. 1, 1999).
GenBank Accession No.: AI907429.1 (Mar. 30, 2000).
GenBank Accession No.: AI909958.1 (Mar. 30, 2000).
GenBank Accession No.: AI917820.1 (Dec. 17, 1999).
GenBank Accession No.: AK000234 (Feb. 22, 2000).
GenBank Accession No.: AK017846.1 (Jul. 5, 2001).
GenBank Accession No.: AK022595.1 (Sep. 29, 2000).
GenBank Accession No.: AL035087.20 (Jul. 27, 2000).
GenBank Accession No.: AL056584 (Jun. 3, 1999).
GenBank Accession No.: AL120271.1 (Feb. 25, 2000).

Affiliated with

Also associated with

Rating

PR/SET-domain containing nucleic acids, polypeptides,... does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with PR/SET-domain containing nucleic acids, polypeptides,..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and PR/SET-domain containing nucleic acids, polypeptides,... will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-3479433