Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving nucleic acid
Patent
1987-09-17
1990-07-17
Kepplinger, Esther M.
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving nucleic acid
435 7, 435 29, 436 64, 436503, 436506, 436544, 436548, 436813, 530352, 530387, 530828, 935 1, 935 6, 935 19, 935110, C12Q 168, G01N 3353, G01N 33567, G01N 33577
Patent
active
049421239
ABSTRACT:
This invention relates in general to a phosphoprotein product of the retinoblastoma susceptibility gene. In particular, this invention relates to a phosphoprotein ppRB.sup.110 primarily located in the cell nucleus which has a DNA binding activity. The invention also relates to the amino acid sequence of the phosphoprotein and to the specific purified anti-retinoblastoma phosphoprotein antibody. The invention further relates to a method of diagnosing retinoblastoma and other retinoblastoma gene involved cancers, treating such kind of cancers and regulating the oncogenicity of other genes.
REFERENCES:
patent: 4735895 (1988-04-01), Kopelovich
Sevier et al., Clin. Chem., vol. 27/11, pp. 1797-1806, 1981.
Murphee et al., Science, vol. 223, Mar. 1984, pp. 1028-1033.
Lee et al., Science, vol. 235, Mar., 1987, pp. 1394-1399.
Lundberg et al., Proc. Natl. Acad. Sci. U.S.A., vol. 84, Apr. 1987, pp. 2372-2376.
Cavence et al., Nature, vol. 305, 27 Oct. 1983, pp. 779-784.
Seizinger et al., Nature, vol. 322, 14 Aug. 1986, pp. 644-647.
-H. P. Lee Eva Y.
Lee Wen-Hwa
Hoffer Florina B.
Kepplinger Esther M.
Kleinke Bernard L.
Potts Jerry R.
The Regents of the University of California
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