ppRB.sup.110 -phosphoprotein the retinoblastoma susceptibility g

Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving nucleic acid

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435 7, 435 29, 436 64, 436503, 436506, 436544, 436548, 436813, 530352, 530387, 530828, 935 1, 935 6, 935 19, 935110, C12Q 168, G01N 3353, G01N 33567, G01N 33577

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049421239

ABSTRACT:
This invention relates in general to a phosphoprotein product of the retinoblastoma susceptibility gene. In particular, this invention relates to a phosphoprotein ppRB.sup.110 primarily located in the cell nucleus which has a DNA binding activity. The invention also relates to the amino acid sequence of the phosphoprotein and to the specific purified anti-retinoblastoma phosphoprotein antibody. The invention further relates to a method of diagnosing retinoblastoma and other retinoblastoma gene involved cancers, treating such kind of cancers and regulating the oncogenicity of other genes.

REFERENCES:
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Murphee et al., Science, vol. 223, Mar. 1984, pp. 1028-1033.
Lee et al., Science, vol. 235, Mar., 1987, pp. 1394-1399.
Lundberg et al., Proc. Natl. Acad. Sci. U.S.A., vol. 84, Apr. 1987, pp. 2372-2376.
Cavence et al., Nature, vol. 305, 27 Oct. 1983, pp. 779-784.
Seizinger et al., Nature, vol. 322, 14 Aug. 1986, pp. 644-647.

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