Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Reexamination Certificate
2006-09-19
2006-09-19
Saeed, Kamal A. (Department: 1626)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
C548S222000
Reexamination Certificate
active
07109226
ABSTRACT:
A compound represented by the following formula (1):Or a salt thereof; and therapeutic durgs containing the compound. The compound selectively activates PPARα.
REFERENCES:
patent: 6653334 (2003-11-01), Yamazaki et al.
patent: WO 97/28149 (1997-08-01), None
patent: WO 02/46176 (2002-06-01), None
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Yong-Xu Wang, et al., “Peroxisome-Proliferator-Activated Receptor δ Activates Fat Metabolism to Prevent Obesity”,Cell, vol. 113, pp. 159-170, Apr. 18, 2003.
Isabelle Issemann et al., “Activation of a member of the steroid hormone receptor superfamily by peroxisome proliferators”,Nature, vol. 347, pp. 645-650., Oct. 18, 1990.
Christine Dreyer, et al., “Control of the Peroxisomal β-Oxidation Pathway by a Novel Family of Nuclear Hormone Receptors”,CELL, vol. 68, pp. 879-887, Mar. 6, 1992.
Letter to the Editor, “A Unified Nomenclature System for the Nucleur Receptor Superfamily”,Cell, vol. 97, pp. 161-163, Apr. 16, 1999.
Kristina Schoonjans, et al., “The peroxisome proliferator activated receptors (PPARs) and their effects on lipid metabolism and adipocyte differentiation”,Biochimica Et Biophysica Acta, vol. 1302, pp. 93-109. (1996).
Timothy M. Willson, et al., “The PPARs: From Orphan Receptors to Drug Discovery”,Journal of Medicinal Chemistry, vol. 43, No. 4, pp. 527-550. Feb. 24, 2000.
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Mauricio Reginato, et al., “Mechanisms by which Thiazolidinediones Enhance Insulin Action”,TEM, vol. 10, No. 1, pp. 9-13. (1999).
Akira Okuno, et al., “Troglitazone Increases the Number of Small Adipocytes Without the Change of White Adipose Tissue Mass in Obese Zucker Rats”,J. Clin Invest., vol. 101, No. 6, pp. 1354-1361, Mar. 1998.
Naoki Sakane, et al., “Glitazones and NIDDM”,The Lancet, vol. 349, pp. 952, Mar. 29, 1997.
Jennifer L. Oberfield, et al., “A peroxisome proliferator-activated receptor y ligand inhibits adipocyte differentiation”,Proc. Natl. Acad. Sci USA, vol. 96, pp. 6102-6106, May 1999.
Harold M. Wright et al., “A Synthetic Antagonist for the Peroxisome Proliferator-activated Receptor y Inhibits Adipocyte Differentiation”,The Journal of Biological Chemistry, vol. 275, No. 3, pp. 1873-1877. (2000).
Toshimasa Yamauchi, et al., “Inhibition of RXR and PPARy ameliorates diet-induced obesity and type 2 diabetes”,The Journal of Clinical Investigation, vol. 108, No. 7, pp. 1001-1013, Oct. 2001.
Didier Auboeuf, et al., “Tissue Distribution and Quantification of the Expression of mRNAs of Peroxisome Prolifertor-Activated Receptors and Liver X Receptor-α in Humans, No Alteration in Adipose Tissue of Obese and NIDDM Patients”,Diabetes, vol. 46, pp. 1319-1327, Aug. 1997.
William R. Oliver, Jr., et al., “A selective peroxisome proliferator-activated recepter δ agonist promotes reverse cholesterol transport”,PNAS, vol. 98, No. 9, pp. 5306-5311, Apr. 2001.
Yong-Xu Wang, et al., “Peroxisome-Proliferator-Activated Receptor δ Activates Fat Metabolism to Prevent Obesity”,Cell, vol. 113, pp. 159-170, Apr. 18, 2003.
Helen Vosper, et al., “The Peroxisome Proliferator-activated Receptor δ Promotes Lipid Accumulation in Human Macropages”,The Journal of Biological Chemistry, vol. 276, No. 47, pp. 44258-44265. (2001).
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Abe Kazutoyo
Araki Takaaki
Nishikawa Masahiro
Oda Soichi
Okuda Ayumu
Barker Michael P.
Kowa Co. Ltd.
Saeed Kamal A.
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