pp: A newly identified CD45-associated protein

Details pp: A newly identified CD45-associated protein pp: A newly identified CD45-associated protein

1994-02-14

1996-04-23

Wax, Robert A.

Chemistry: natural resins or derivatives; peptides or proteins;

Proteins, i.e., more than 100 amino acid residues

5303879, 435 6, C12Q 168, C07K 100, C07K 1400, C07K 1600

Patent

active

055104614

ABSTRACT:
This invention relates to a newly identified protein useful for treating diseases of the immune system, methods for obtaining said protein, isolated nucleic acids encoding said protein, and methods for obtaining inhibitors of said protein. The protein of this invention is characterized by an apparent molecular weight of about 32 kD, an isoelectric point of about 4.0-4.5 and coprecipitation with CD45. The protein may also be used in in vitro or in vivo assays to identify inhibitors of T cell activation.

REFERENCES:
Altin, J. B. et al. (1994) "Evidence for an Association of CD45 with 32000-33000 MW Phosphoprotein of Murine T and B Lymphocytes", Immunology vol. 83, pp. 420-429.
Brown et al. (1994) "Multiple Components of the B Cell Antigen Receptor Complex Associate with the Protein Tyrosine Kinase Phosphatase, CD45", J. Biol. Chem., vol. 269, No. 25, pp. 17238-17244.
Schraven, B. et al. (1994) "LPAP, a Novel 32-kDa Phosphoprotein that Interacts with CD45 in Human Lymphocytes", J. Biol. Chem., vol. 269, No. 46, pp. 29102-29111.
Schraven, B. et al. (1992) "Four CD45/P56lck-associated Phosphoproteins (pp. 29-pp. 32) Undergo Alterations in Human T Cell Activation", Eur. J. Immunol., vol. 22, No. 7, pp. 1857-1863.
Schraven, B. et al., (1992) "Four CD45/56lck-associated Phosphoproteins (pp. 29-pp. 32) Undergo Alterations in Human T Cell Activation", Chemical Abstracts, vol. 117, No. 15, Abstract No. 149228.
Takeda et al., "Molecular Cloning of the CD45-associated 30-kDa Protein", The Journal of Biological Chemistry, vol. 269, No. 4, pp. 2357-2360, (Jan. 28, 1994).
Gyuris et al., "Cdi1, a Human G1 and S Phase Protein Phosphatase That Associates with Cdk2", Cell, vol. 75, pp. 791-803, (Nov. 19, 1993).
Tonks et al., "CD45, an Integral Membrane Protein Tyrosine Phosphatase", The Journal of Biological Chemistry, vol. 265, No. 18, pp. 10674-10680, (Jun. 25, 1990).
Schraven et al., "Triggering of the alternative pathway of human T cell activation involves members of the T 200 family of glycoproteins", European Journal of Immunology, vol. 19, pp. 397-403, (1989).
Ross et al., "The Association Between CD45 and LCK Does Not Require CD4 Or CD8 And Is Independent of T Cell Receptor Stimulation," Biochemical and Biophysical Research Communications, vol. 198, No. 1, pp. 88-96, (1994).
Schraven et al., "Alterations of CD2 association with T cell receptor signaling molecules in `CD2 unresponsive` human T lymphocytes," European Journal of Immunology, vol. 23, pp. 119-123, (1993).
Schraven et al., "Four CD45/P56.sup.lck -associated phosphoproteins (pp. 29-pp. 32) undergo alterations in human T cell activation" European Journal of Immunology, vol. 22, pp. 1857-1863, (1992).
Schraven et al., "A functional complex is formed in human T lymphocytes between the protein tyrosine phosphatase CD45, the protein tyrosine kinase p56.sup.lck and p. 32, a possible common substrate", European Journal of Immunology, vol. 21, pp. 2469-2477, (1991).
Kiener, et al. (1989), J. Immunol. 143(1):23-28.

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