Poxvirus containing formulations and process for preparing...

Details Poxvirus containing formulations and process for preparing... Poxvirus containing formulations and process for preparing...

2006-08-22

2006-08-22

Mosher, Mary E. (Department: 1648)

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Virus or component thereof

C424S199100, C435S235100, C435S239000

Reexamination Certificate

active

07094412

ABSTRACT:
The present invention relates to a formulation, in particular an aqueous formulation comprising (i) a poxvirus of one of the generaorthopoxvirus, avipoxvirus, parapoxvirus, capripoxvirusandsuipoxvirus, (ii) a disaccharide, (iii) a pharmaceutically acceptable polymer and optionally (iv) a buffer. The aqueous formulation is particularly suitable for freeze drying processes resulting in a stable, freeze-dried, poxvirus containing composition. The invention further concerns a method for preparing a freeze-dried, poxvirus containing composition and the thus obtained product.

REFERENCES:
patent: 3577526 (1971-05-01), Valette
patent: 3915794 (1975-10-01), Zygraich et al.
patent: 4380582 (1983-04-01), Orlando et al.
patent: 5185146 (1993-02-01), Altenburger
patent: 5792643 (1998-08-01), Herrmann et al.
patent: 6258362 (2001-07-01), Loudon et al.
patent: 299 213 (1992-04-01), None
patent: 7 773 (1970-03-01), None
patent: WO 98/13500 (1998-04-01), None
patent: WO 00/34444 (2000-06-01), None
Formulation, Stability and Deliver of Live . . . By Burke et al. (Critical Review—Jan. 1999).

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