Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Carbohydrate doai
Patent
1988-02-04
1989-05-30
Schenkman, Leonard
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Carbohydrate doai
514180, A61K 31715, A61K 3156
Patent
active
048351423
ABSTRACT:
A powdery pharmaceutical composition for application to the mucosa of the oral or nasal cavity including: (a) a base selected from the group consisting of lower alkyl ethers of cellulose; (b) a pharmaceutically effective amount of a drug selected from the group consisting of steroid or glycyrrhizic acid type anti-inflammatory agents; and (c) a stabilizer for the drug composed of at least one low irritant solid organic acid selected from the group consisting of saturated higher aliphatic monocarboxylic acids having 12 or more carbon atoms, aliphatic polycarboxylic acid, hydroxy aliphatic polycarboxylic acids, aromatic carboxylic acids, unsaturated lower aliphatic monocarboxylic acids having six or less carbon atoms, and cellulose derivatives having carboxyl group.
This powdery pharmaceutical composition has extremely excellent stability in the steroid or glycyrrhizic acid type anti-inflammatory agent contained therein, low irritation of the mucosa of the oral or nasal cavity, and sustained release of the drug over an extended period of time.
REFERENCES:
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patent: 4246040 (1981-01-01), Okamura et al.
patent: 4289764 (1981-09-01), Yarrow et al.
patent: 4294829 (1981-10-01), Suzuki et al.
patent: 4294952 (1981-10-01), Wildnauer
patent: 4389393 (1983-06-01), Schor et al.
Chemical Abstracts; vol. 93 (1980) #179506q; Nasyrov et al.
Ikura Hiroshi
Suzuki Yoshiki
Lipovsky Joseph A.
Schenkman Leonard
Teijin Limited
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