Powders

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2006-01-24

2006-01-24

Azpuru, Carlos A. (Department: 1615)

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Particulate form

C424S489000, C428S402000

Reexamination Certificate

active

06989155

ABSTRACT:
Particles of an amino acid such as leucine may be formed from an amino acid vapor, for example by aerosol condensation, or by spray drying. The amino acid particles have a bulk density of not more than 0.1 gcm−3or have a mass median aerodynamic diameter of not more than 10 μm or are in the form of flakes having a thickness of not more than 100 μm. The inclusion of the particles of amino acid in powder for use in dry powder inhalers has been found to improve the respirable fraction of the active material in the powder.

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Edwards, et al.; Large Porous Particies for Pulmonary Drug Delivery;Science,vol. 276, Jun. 20, 1997; pp. 1868-1871.
Yamashita et al.; A Novel Formulation of Dry Powder for Inhalation of Peptides and Proteins;Respiratory Drug Delivery,VI, 1998; pp. 483-485.
G. Röschelsen et al.; Preparation and Optimization of L-leucine as Lubricant for Effervescent Tablet Formulations;Pharmaceutica Acta Helvetiae70 (1995); pp. 133-139.
International Search Report; PCT/GB99/04156; Jun. 28, 2000.

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