Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Particulate form
Patent
1993-12-21
1994-11-15
Kight, III, John
Drug, bio-affecting and body treating compositions
Preparations characterized by special physical form
Particulate form
424493, 424498, 424 49, 424 57, 428403, 428404, C11D 166, A61K 716
Patent
active
053646479
DESCRIPTION:
BRIEF SUMMARY
This invention relates to free-flowing powder-form preparations of surface-active alkyl glycosides and to a process for their production by drying of an aqueous mixture of alkyl glycoside and inert particulate support materials.
Surface-active alkyl glycosides in the context of the present invention are the reaction products of sugars and aliphatic primary alcohols preferably containing 8 to 22 carbon atoms. The sugar components, which are referred to hereinafter as glycoses, are preferably glucose and also fructose, mannose, galactose, talose, gulose, allose, altrose, idose, arabinose, xylose, lyxose, ribose and mixtures thereof.
The acetalization products of glucose with fatty alcohols obtainable, for example, from natural fats and oils by known methods, i.e. with linear, primary, saturated and unsaturated C.sub.8-22 alcohols, are preferred by virtue of their ready availability and their good performance properties. Accordingly, the invention preferably relates to these types of alkyl glycosides which are also referred to hereinafter as alkyl glucosides.
Where they are produced by known methods for example in accordance with U.S. Pat. No. 3,839,318 or EP 132 046 A1, alkyl glycosides are accompanied by different residual quantities of unreacted starting products, among which the fatty alcohol is particularly troublesome in many applications. The crude acetalization products are solid, solidified melts which cannot be cast or dispersed at normal temperature.
In one particularly preferred production process, glucose is acetalized with fatty alcohol, water being continuously distilled off from the mixture under reduced pressure. In this production process, which is described in detail in German patent application P 38 33 780.0, the crude alkyl glucoside is obtained in the form of a solidified melt containing approximately 63% by weight fatty alkyl monoglucoside, 15% by weight fatty alkyl diglucoside, 6% by weight fatty alkyl triglucoside, 3% by weight alkyl tetraglucoside, 6% by weight polyglucose and 2 to 4% by weight residual fatty alcohol. Attempts to convert this melt by spray drying, flaking or granulation into a particulate product which flows freely at normal temperature resulted in the formation of tacky, moisture-sensitive materials. In addition, the unreacted residual fatty alcohol still present in the product is noticeable by its unpleasant taste where the alkyl glucosides are used in oral and dental hygiene preparations. However, oral and dental hygiene preparations represent a preferred application for surface-active alkyl glycosides by virtue of their compatibility with mucous membrane.
Accordingly, the problem addressed by the invention was to convert surface-active alkyl glycosides into a pourable, free-flowing form in which they could readily be stored, transported, distributed and incorporated without difficulty in other products, particularly in oral and dental hygiene preparations.
Accordingly, the present invention relates to powder-form preparations of surface-active alkyl glycosides which are characterized in that the contain 5 to 65% by weight of a surface-active alkyl glycoside and 35 to 95% by weight of an inert support and which are obtained by drying of a pourable, aqueous mixture of crude alkyl glycoside and support.
In the context of the invention, a crude alkyl glycoside is understood to be the crude product obtained in the known production process with the secondary constituents attributable to the process, more particularly the reaction mixture containing 2 to 5% by weight unreacted fatty alcohols obtained by the acetalization process described above.
Suitable supports are any chemically and physiologically inert, inorganic support materials which show a substantially neutral or, at best, mildly basic reaction in water and which accumulate in powder form after drying. Particularly preferred supports are substances which are not troublesome when used in oral and dental care preparations, for example in toothpastes, for example because they are already required in another capac
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Foerg Franz
Hill Karlheinz
Koerner Hermann
Penninger Josef
Culpeper Mullis Jeffrey
Henkel Kommanditgesellschaft auf Aktien
Jaeschke Wayne C.
Kight III John
Ortiz Daniel S.
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