Powder-layered oral dosage forms

Details Powder-layered oral dosage forms Powder-layered oral dosage forms

2006-06-13

2006-06-13

Padmanabhan, Sreeni (Department: 1616)

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Capsules

C424S458000, C424S490000, C424S493000

Reexamination Certificate

active

07060293

ABSTRACT:
An oral dosage form of morphine is formulated by powder-layering an homogeneous mixture of morphine sulfate and hydrous lactose impalpable onto inert beads to obtain a multiparticulate product. A plurality of the powder-layered beads may be administered either in immediate release form or in an extended release form by coating with a hydrophobic material. In addition, multi-particulate oral dosage forms containing therapeutically effective agents containing a plurality of pharmaceutically acceptable inert beads powder-layered with homogeneous mixture of a therapeutically effective agent and hydrous lactose impalpable are also disclosed. A method of preparing the dosage forms as well as a method preparing spheroids containing the homogeneous mixture of therapeutically effective agent and hydrous lactose impalpable are also disclosed.

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