Powder formulation

Details Powder formulation Powder formulation

2002-08-19

2008-03-18

Sheikh, Humera N (Department: 1618)

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Particulate form

C424S493000

Reexamination Certificate

active

07344734

ABSTRACT:
The invention relates to a powder formulation for administration by inhalation comprising an active substance and a pharmaceutically acceptable excipient, which composition has the form of a physical mixture and comprises from 5 to 25 wt. % of the excipient, and wherein the active substance has a particle size distribution of from 0.5 to 10 μm, and wherein the excipient has a particle size distribution of from 15 to 500 μm.

REFERENCES:
patent: 3634582 (1972-01-01), Hartley et al.
patent: 5301666 (1994-04-01), Lerk et al.
patent: 5478578 (1995-12-01), Arnold et al.
patent: 6027714 (2000-02-01), Trofast
patent: 1792207 (1971-11-01), None
patent: 0 876 814 (1998-11-01), None
patent: 10 08019 (1999-02-01), None
patent: WO 95/11666 (1995-05-01), None
patent: WO 96/23485 (1996-08-01), None
patent: WO 97/03649 (1997-02-01), None
patent: WO 9703649 (1997-02-01), None
patent: WO 98/20836 (1998-05-01), None
patent: WO 9820836 (1998-05-01), None
patent: WO 98/26827 (1998-06-01), None
patent: WO 9826827 (1998-06-01), None
patent: WO 00/16745 (2000-03-01), None
patent: WO 0016745 (2000-03-01), None
R. Clark Andrew, The use of laser diffraction for the evaluation of the aerosol clouds generated byInt. J. Pharm., 115;69-78 (1995).
Annapragada et al., “An analysis of the Fraunhofer Differaction method for particle size distribution analysis and its application to aerosolized sprays,”Int. J. Pharm., 127:219-227 (1996).
Edwards et al., “Large Porous Particles for Pulmonary Drug Delivery,”Science, 276:1868-1871 (1997).
Hersey, “Ordered Mixing: A New Concept in Powder Mixing Practice,”Powder Tech., 11:41-44 (1975).
Higham et al., “Determination of the minimum dose of lactose drug carrier that can be sensed during inhalation,”J. Clin. Pharmacol., 40:281-282 (1995).
Hindle et al., “Cascade impaction methods for dry powder inhalers using the high flowrate Marple-Miller Impactor,”Int. J. Pharma., 134:137-146 (1996).
Lacey, “The Mixing of Solid Particles,”Trans. Inst.Chem.. Engineers, 21:53-59 (1943).
Lowry et al., “Protein Measurement with the Folin Phenol Reagent,”J. Biol. Chem., 193:265-275 (1951).
Olsson et al., “The use of inertial impactors to measure the fine particle dose generated by inhalers,”Pharmeuropa, 8:291-298 (1996).
Staniforth, “Order out of chaos,”J. Pharma. Pharmacol., 39:329-334 (1987).
Timsina et al., “Drug delivery to the respiratiory tract using dry powder inhalers,”Int. J. Pharm., 101:1-13 (1994).
Travers et al., “The mixing of micronized sodium bicarbonate with sucrose crystals,”J. Pharma. Pharmac., 23 Suppl:260S-261S (1971).
English abstract of DE 1792207.
English abstract of NL 1008019.

Affiliated with

Also associated with

Rating

Powder formulation does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Powder formulation, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Powder formulation will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-3975635