Powder formation by atmospheric spray-freeze drying

Details Powder formation by atmospheric spray-freeze drying Powder formation by atmospheric spray-freeze drying

2006-03-07

2006-03-07

Gravini, S. (Department: 3749)

Drying and gas or vapor contact with solids

Process

Freeze-drying

C034S299000, C034S092000

Reexamination Certificate

active

07007406

ABSTRACT:
A method of manufacturing heat-sensitive pharmaceutical powder is disclosed. The original pharmaceutical substances are dissolved in a solution or suspended in a suspension, which is sprayed through an atomizing nozzle and frozen in a cold gas phase or liquid nitrogen atomized directly in the spray-freeze chamber or gas jacket at the same time (for cooling purposes). The particles are freeze-dried at roughly atmospheric pressure in a down-stream fluid flow with exit filter thereby to remove moisture entrapped on or inside the frozen particles. The system has applicability for forming other powders.

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S. Wayne Klein , Sol H. Goodgal, “Sublimation Freeze-Drying without Vacuum”, Science, 1969, 130: 628-629.

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