Powder formation by atmospheric spray-freeze drying

Details Powder formation by atmospheric spray-freeze drying Powder formation by atmospheric spray-freeze drying

2008-04-29

2008-04-29

Gravini, S. (Department: 3749)

Drying and gas or vapor contact with solids

Process

Freeze-drying

Reexamination Certificate

active

07363726

ABSTRACT:
A method of manufacturing heat-sensitive pharmaceutical powder is disclosed. The original pharmaceutical substances are dissolved in a solution or suspended in a suspension, which is sprayed through an atomizing nozzle and frozen in a cold gas phase or liquid nitrogen atomized directly in the spray-freeze chamber or gas jacket at the same time (for cooling purposes). The particles are freeze-dried at roughly atmospheric pressure in a down-stream fluid flow with exit filter thereby to remove moisture entrapped on or inside the frozen particles. The system has applicability for forming other powders.

REFERENCES:
patent: 3290788 (1966-12-01), Seelandt
patent: 5208998 (1993-05-01), Oyler, Jr.
patent: 5417153 (1995-05-01), King et al.
patent: 6862890 (2005-03-01), Williams et al.
patent: 2003/0092145 (2003-05-01), Jira et al.

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