Potentiophotometric fibrinogen determination

Details Potentiophotometric fibrinogen determination Potentiophotometric fibrinogen determination

1990-09-27

1993-03-23

Lall, Parshotam S.

Boots, shoes, and leggings

36441309, 435 13, 422 73, 436 69, G01N 3386, C12Q 156

Patent

active

051970171

ABSTRACT:
The fibrinogen concentration of a blood plasma sample is measured and simultaneously the prothrombin time is determined. Potentiophotometric apparatus is used in which the output signal is applied to an analog/digital converter and digital recorder. Digital voltage values are developed and then printed in an array. A computer records digital voltage values produced by the apparatus with a plasma sample in the test tube before injection of thromboplastin. The time of the injection is identified by a substantial change in the recorded voltage values. After a short time delay the digital voltage value is noted and thereafter this voltage value is compared with a second voltage value. A difference of three or more identifies the beginning of clotting. The first of the two voltage numbers is identified x and is compared with the voltage value 60 seconds later, which is identified y. The delta voltage value is y-x. The delta voltage values for two samples of known but different fibrinogen concentrations, one high and one low, are plotted on a linear calibration curve drawn, which is used to determine the fibrinogen concentration values of plasma samples having unknown fibrinogen concentration.

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