Potentiators of insulin secretion

Details Potentiators of insulin secretion Potentiators of insulin secretion

2011-01-04

2011-01-04

Weddington, Kevin (Department: 1614)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

C514S866000

Reexamination Certificate

active

07863301

ABSTRACT:
The present invention relates to a recognition that an analog of αKG can increase glucose-induced insulin secretion in vitro and in vivo in animals, particularly in mammals, and more particularly in humans and in rodents. By employing the methods of the invention, insulin secretion can be increased.

REFERENCES:
patent: 2980687 (1961-04-01), Carmack et al.
patent: 4717727 (1988-01-01), Gunzler et al.
patent: 5427940 (1995-06-01), Newgard
patent: 5801193 (1998-09-01), Ojo-Amaize et al.
patent: 5914339 (1999-06-01), Sum et al.
patent: 5993799 (1999-11-01), Newgard
patent: 6020361 (2000-02-01), Venkatesan
patent: 61171417 (1986-08-01), None
patent: 2000/351731 (2000-12-01), None
patent: WO 99/01432 (1999-01-01), None
patent: WO 01/23347 (2001-04-01), None
patent: WO 01/92273 (2001-12-01), None
patent: WO 02/39997 (2002-05-01), None
patent: WO 03/053915 (2003-07-01), None
Blank, B. et al., Mercapto Heterocyclic carboxylic acids, analogues of 3-mercaptopicolinic acid, J Med. Chem. 20(4):572-576 (1977).
Blank, B. et al, Mercaptopyridinecarboxylic acids, synthesis and hypoglycemic activity, J. Med. Chem. 17(10):1065-1071 (1974).
Schneid, C., In vivo induction of insulin secretion by ornithine a-ketoglutarate: Involvement of nitric oxide and glutamine, Metabolism 52(3):344-350 (2002).
Kikuchi, A. et al., Stimulatory effect of a sulfonylurea analogue and its polymer conjugate on insulin secretion from rat islets, Biotechnol. Prog. 10:630-635 (1994).
Asfari, M., et al., 1992“Establishment of 2-Mercaptoethanol-Dependent Differentiated Insulin-Secreting Cell Lines,” Endocrinology 130:167-178.
Best, L. (1997) “Glucose and alpha-ketoisocaproate induce transient inward currents in rat pancreatic beta cells,” Diabetologia 40:1-6.
Branstrom, R., et al., (1998) “Direct Inhibition of the Pancreatic Beta-Cell ATP-Regulated Potassium Channel by Alpha-Ketoisocaproate,” J. Biol. Chem. 273:14113-14118.
Bryan, J., et al., (1999) “Sulfonylurea receptors: ABC transporters that regulate ATP-sensitive K+ channels,” Biochim. Biophys. Acta 1461:285-303.
Gao, Z., et al., (2003) “Distinguishing Features of Leucine and Alpha-Ketoisocaproate Sensing in Pancreatic Beta-Cells,” Endocrinology 144:1949-1957.
Gembal, M., et al., (1992) “Evidence that glucose can control insulin release independently from its action on ATP-sensitive K+ channels in mouse B cells,” J. Clin. Invest. 89:1288-1295.
Hanson, R.L., et al. (1998) “An Autosomal Genomic Scan for Loci Linked to Type II Diabetes Mellitus and Body-Mass Index in Pima Indians,” Am. J. Hum. Genet. 63:1130-1138.
Hohmeier, H.E., et al., (2000) “Isolation of INS-1-Derived Cell Lines With Robust ATP-Sensitive K+ Channel-Dependent and -Independent Glucose-Stimulated Insulin Secretion” Diabetes 49:424-430.
Malaisse, W.J., et al., (1981) “The stimulus-secretion coupling of amino acid-induced insulin release. Metabolic interaction of L-glutamine and 2-ketoisocaproate in pancreatic islets.” Biochim. Biophys Acta 677:39-49.
Obici, S., et al., (2001) “Central Administration of Oleic Acid Inhibits Glucose Production and Food Intake,” Rapid Publication.
Obici, S., et al., (2002) “Hypothalamic insulin signaling is required for inhibition of glucose production,” Nature Medicine 8:1376-1382.
Obici, S., et al., (2003) “Inhibition of hypothalamic camitine palmitoyltransferase-1 decreases food intake and glucose production,” Nature Medicine 9:756-761.
Persuad, S.J., et al, (1999) “Tyrosine kinases play a permissive role in glucose-induced insulin secretion from adult rat islets,” Journal of Molecular Endocrinology 22:19-28.
Stanley, C.A., et al., (1998) “Hyperinsulinism and hyperammonemia in infants with regulatory mutations of the glutamate dehydrogenase gene,” N. Engl. J. Med. 338:1352-1357.
Straub, S.G., et al., (2002) “Glucose-stimulated signaling pathways in biphasic insulin secretion,” Diabetes Metab. Res. Rev. 18:451-463.
Straub, S.G., et al., (2003) “Stimulation of insulin secretion by denatonium, one of the most bitter-tasting substances known,” Diabetes 52:356-364.

Affiliated with

Also associated with

Rating

Potentiators of insulin secretion does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Potentiators of insulin secretion, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Potentiators of insulin secretion will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-2698831