Potentiators of antibacterial agents

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai

Patent

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

514 11, 514 29, 514 37, 514 39, 514152, 514153, 514154, 514197, 514198, 514199, 514312, A61K 3143, A61K 3171, A61K 3812, A61K 3814

Patent

active

058830740

ABSTRACT:
Methods for screening for compounds which potentiate the activity of antibacterial agents against bacteria resistant to the antibacterial agent alone, pharmaceutical compositions including such potentiators, and methods of treating bacterial infections using a combination of a potentiator and a potentiated antibacterial agent, which are useful for overcoming the resistance of a bacterial strain for an antibacterial agent.

REFERENCES:
patent: 2809996 (1957-10-01), Stoll
patent: 3792167 (1974-02-01), Fried et al.
patent: 3898330 (1975-08-01), McGinty
patent: 3940478 (1976-02-01), Kurtz
patent: 4134972 (1979-01-01), Atherton et al.
patent: 4153686 (1979-05-01), Nagel
patent: 4560553 (1985-12-01), Zupan
patent: 4621137 (1986-11-01), Miyake et al.
patent: 5198419 (1993-03-01), Ando et al.
patent: 5221664 (1993-06-01), Berkowitz et al.
patent: 5277907 (1994-01-01), Loria
patent: 5358752 (1994-10-01), Evans et al.
patent: 5453276 (1995-09-01), Nakatsu et al.
patent: 5478819 (1995-12-01), Tarpila et al.
patent: 5543417 (1996-08-01), Waldstreicher
patent: 5587358 (1996-12-01), Sukigara et al.
patent: 5616568 (1997-04-01), Pouyani et al.
patent: 5646023 (1997-07-01), Secor et al.
Chemical Abstracts 101:3824 m (Jul. 2, 1984).
Kirk-Othmer Encyclopedia of Chemical Technology, 3rd ed. New York: John Wiley & Sons, vol. 22, p. 753, 1983.
The Merck Index, 10.sup.th ed. Rahway: Merck & Co., Inc. pp. 248, 631, 758, 759, 1259, 1983.
Piccinini et al. Effect of terpenes on The Cell Permeability . . . Advances in Antimicrobial and Antineoplastic Chemotherapy. pp. 855-857, 1972.
Allen et al. 7-Hydroxytropolone: an Inhibitor of Aminoglycoside . . . Antimicrobial Agents and Chemotherapy, Nov. 1982, vol. 22, No. 5, pp. 824-831.
Smith et al. Effects of Intravitreal Dexamethasone on Concentration . . . Antimicrobial Agents and Chemotherapy, Jul. 1991, vol. 35, No. 7, pp. 1298-1302.
Arthur & Courvalin, "Genetics and Mechanisms of Glycopeptide Resistance in Enterococci," Antimicrob. Agents Chemother. 37:1563-1571 (1993).
Berger-Bachi and Kohler, FEMS Microbiol. Lett. 20:305-309 (1983).
Blickenstaff et al., "Total Synthesis of Steroids," Organic Chemistry vol. 30, 1974 (Table of Contents).
Bryan and Godfrey, ".beta.-Lactam Antibiotics: Mode of Action and Bacterial Resistance, Ch. 16" in Antibiotics in Laboratory Medicine, 3rd Ed., Lorian ed. pp. 599-663 (1991).
Chambers, "Methicillin-Resistant Staphylococci," Clin. Microb. Rev. 1:173-186 (1988).
Collins et al., "Immunoglobulin G: Potentiation of Tobramycin and Azlocillin in the Treatment of Pseudomonas aerugionsa Sepsia in Neutropenic Mice and Neutralization of Exotoxin A in Vivo," Review Infect. Dis. 8:S420-S425 (1986).
De Jonge et al., "Altered Muropeptide Composition in Staphylococcus aureus Strains with an Inactivated femA Locus," J. Bacteriol. 17:2779-2782 (1993).
De Lencastre et al., "Molecular aspects of methicillin resistance in Staphylococcus aureus," J. Antimicrob. Chemother. 33:7-24 (1994).
Donowitz and Mandell, "Beta-Lactam Antibiotics," N. Engl. J. Med. 318:419-426 (1988).
Elion et al., "Antagonists of Nucleic Acid Derivatives. VIII. Synergisms in Combinations of Biochemically Related Antimetabolites," J. Biol. Chem.. 208:477-488 (1954).
Eliopolous & Moellering, "Ch. 13--Antimicrobial Combinations," in Antibiotics in Laboratory Medicine, 3rd ed., Lorian ed., at pp. 434-441 (1991).
Fontana et al., Antimicrob. Agents and Chemother. 38:1980-1983 (1994).
Gustafson et al., "The femC Locus of Staphylococcus aureus Required for Methicillin Resistance Includes the Glutamine Synthetase Operon," J. Bacteriol. 176:1460-1467 (1994).
Hartman and Tomasz, "Expression of Methicillin Resistance in Heterogeneous Strains of Staphylococcus aureus," Antimicrob. Agents Chemother. 29:85-92 (1986).
Henze et al., "Influence of femB on Methicillin Resistance and Peptidoglycan Metabolism in Staphylococcus auerus," J. Bacteriol. 175:1612-1620 (1993).
Kornblum et al., Eur. J. Clin. Microbiol. 5:714-718 (1986).
Leclercq et al., N. Engl. J. Med. 319:157-161 (1988).
Lencastre & Tomasz, Antimicrob. Agents Chemother. 38:2590-2598 (1994).
Lorian, Antibiotics in Laboratory Medicine, 3rd ed., pp. 72-78 (1991).
Maidhof et al., "femA, Which Encodes a Factor Essential for Expression of Methicillin Resistance, Affects Glycine Content of Petpidoglycan in Methicillin-Resistant and Methicillin-Susceptible Staphylococcus aureus Strains," J. Bacteriol. 173:3507-3513 (1991).
Murakami and Tomasz, "Involvement of Multiple Genetic Determinants in High-Level Methicillin Resistance in Staphylococcus aureus," J. Bact. 171:874-879 (1989).
Murakami et al., "Production of Low-Affinity Penicillin-Binding Protein by Low- and High-Resistance Groups of Methicillin-Resistant Staphylococcus aureus," Antimicrob. Agents Chemother. 31:1307-1311 (1987).
NCCLS publication entitled Methods for Dilution Antimicrobial Susceptibility Tests (1991).
Neu, "The Crisis in Antibiotic Resistance," Science 257:1064-1073 (1992).
Ryffel et al., Antimicrob. Agents Chemother. 38: 724-728 (1994).
Uttley et al., Epidemiol. Infect. 103:173-181 (1989).
Vogelman et al., "In Vivo Postantibiotic Effect in a Thigh Infection in Neutropenic Mice," J. Infect. Dis. 157:287-298 (1988).
Williamson et al., J. Gen. Microbiol. 131:1933-1940, 1985.
Luckner, "Ch. 5--The biosynthesis of secondary natural products from activated isoprene," Secondary metabolism in plants and animals, translated by Mr. T.N. Vasudevan, Academic Press, N.Y., pp. 122-163 (1972) .

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Potentiators of antibacterial agents does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Potentiators of antibacterial agents, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Potentiators of antibacterial agents will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-817778

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.