Potentiation of the thrombolytic effect of prourokinase type pla

Details Potentiation of the thrombolytic effect of prourokinase type pla Potentiation of the thrombolytic effect of prourokinase type pla

1988-11-02

1991-09-24

Stone, Jacqueline

Drug, bio-affecting and body treating compositions

Enzyme or coenzyme containing

Multienzyme complexes or mixtures of enzymes

424 9463, 424 9464, 435215, 435216, 435219, 435226, A61K 3754, A61K 37547, C12N 950, C12N 970

Patent

active

050512641

ABSTRACT:
The thrombolytic effect of known plasminogen activators such as tissue plasminogen activator (t-PA), prourokinase and modifications of t-PA and prourokinase is enhanced dramatically and unexpectedly when combined with streptokinase. The body is treated with a combination streptokinase and one or more plasminogen activators of the t-PA or prourokinase type to achieve an enhanced effect which has advantage in thrombolytic therapy including the treatment of myocardial infarction.

REFERENCES:
patent: 4178368 (1979-12-01), Heimburger et al.
Verstraete et al., Blood, vol. 67, No. 6, (1986) pp. 1529-1541.

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