Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...
Patent
1997-05-07
2000-03-21
Stucker, Jeffrey
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving antigen-antibody binding, specific binding protein...
435 771, 435 772, 424 9464, G01N 3353, G01N 33567, A61K 3848
Patent
active
060401451
ABSTRACT:
A method for stimulating proliferation of T-cells containing cytoplasmic post-prolyl dipeptidase activity; the method, in one aspect, involves contacting the T-cells with an organic compound at a concentration below 10.sup.-8 M, wherein the compound is characterized in that: (a) it is capable of crossing the membrane of T-cells to enter the cytoplasm, (b) it binds to the dipeptidase activity at a concentration of below 10.sup.-8 M, and thus (c) stimulates proliferation of the T-cells at that concentration.
REFERENCES:
patent: 5329028 (1994-07-01), Ashkenzi et al.
Schmitz, et al, "Potentiation of the immune response . . . " J. Clin. Invest. 97(6): 1545-1549, 1996.
Kubota, et al, "Involvement of dipeptidyl . . . " Clin. Exp. Immunol. 89: 192-197, 1992.
Flentke, et al, "Inhibition of dipeptidyl amino-peptidase . . . " PNAS 88: 1556-1559, 1991.
Markowitz, et al. : A preliminary study if ritonavir . . . : N.E.J.M.: vol. 333, No. 23:pp. 1534-1539, Dec. 1995.
Wijdenes et al., "Monoclonal Antibodies (mAb) against gp130 Imitating Cytokines Which Use the gp130 for Signal Transduction", (Jul. 1995), p. 303.
Blumenstein et al., Biochem. Biophys. Res. Comm. 163:980-987.
"Update on Viral Pathogenesis," by Ronald B. Luftig, ASM News 56:368, 1990.
"Inhibition of Human Immunodeficiency Virus Type 1 Infection in a T-Cell Line (CEM) by new Dipeptidyl-Peptidase IV (CD26) Inhibitors," J.D. Jiang et al., Res. Virol., 1997, 148, pp. 255-266.
"Structure-Activity Relationships of Boronic Acid Inhibitors of Dipeptidyl Peptidase IV. 1. Variation of the P.sub.2 Position of X.sub.aa -boroPro Dipeptides," Simon J. Coutts et al., J. Med. Chem. 1996, 39, pp. 2087-2094.
"Generation and Use of Nonsupport-Bound Peptide and Peptidomimetic Combinatorial Libraries," J.M. Ostresh et al., Methods in Enzymology, vol. 267, Chapter 13, edited by John N. Abelson, 1996, Academic Press, San Diego, ISBN 0-12-182168-4.
Huber Brigitte T.
Schmitz Tracy
Underwood Robert
Elrifi Ivor R.
Levin Mintz
Nelson Brett
Stucker Jeffrey
Tufts University
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