Potentiation of immunotoxin action by Brefeldin A

Details Potentiation of immunotoxin action by Brefeldin A Potentiation of immunotoxin action by Brefeldin A

1991-06-05

1992-05-12

Schain, Howard E.

Drug, bio-affecting and body treating compositions

Lymphokine

530370, 530371, 530377, 530395, 530403, 530404, 530405, 530406, 5303917, 53038822, 424 855, 424 88, 424 89, 424 92, A61K 3939, A61K 39395

Patent

active

051126079

ABSTRACT:
A method of potentiating immunotoxin action in an immunotoxin/target-cell stem in which Brefeldin A is utilized as an immunopotentiator. The Brefeldin A enhances the immunotoxin pathway while blocking or inhibiting the nonspecific pathway, thus being particularly useful in conjunction with immunotoxins made from holotoxins. The Brefeldin A is effective in small, nontoxic concentrations and therefore may be utilized with either in vivo or in vitro systems.

REFERENCES:
patent: 4439199 (1984-03-01), Amkraut et al.
patent: 4490362 (1984-12-01), Shionoya et al.
patent: 4582703 (1986-04-01), Jansen et al.
patent: 4664911 (1987-05-01), Uhr et al.
patent: 4749566 (1988-06-01), Casellas et al.
patent: 4911911 (1990-03-01), Casellas et al.
patent: 4911912 (1990-03-01), Casellas et al.
patent: 4980457 (1990-12-01), Jansen
Merck Index, 10th ed., 1983, p. 189.

Affiliated with

Also associated with

Rating

Potentiation of immunotoxin action by Brefeldin A does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Potentiation of immunotoxin action by Brefeldin A, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Potentiation of immunotoxin action by Brefeldin A will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-2425742